Aj;nuary,Fimm'}     Approved  Proprietary  Preparations.  31 
uterus  on  tampons,  and  by  suppository  for  painful  pelvic  affections 
generally  ;  but  there  is  no  evidence  that  it  produces  any  local 
anesthetic  action.  Manufactured  by  Farbenfabriken,  vorm.  Friedr- 
Bayer  &  Co.,  Elberfeld,  Germany  (Continental  Color  and  Chemical 
Co.,  New  York).    U.  S.  trade-mark. 
HEXAMETHYLENAMINE  METHYLENCITRATE.1 
This  substance,  C6HsOT(CH2)6N4  =  C12H20O7N4,  is  a  compound  of 
hexamethylenamine  with  anhydromethylencitric  acid. 
Actions  and  Uses. — It  is  a  urinary  antiseptic  and  germicide 
claimed  to  be  more  prompt  and  energetic  in  its  action  then  hexa- 
methylenamine, acting  equally  well  whether  the  urine  be  alkaline  or 
acid  in  reaction,  rapidly  clearing  it  up  and  allaying  pain.  It  is 
recommended  in  cystitis,  pyelitis,  prostatic  diseases  and  urethritis. 
It  is  also  recommended  as  an  efficient  urinary  antiseptic  in  infectious 
diseases  in  which  bacteria  are  present  in  the  urine,  as  in  typhoid 
fever.  It  is  regarded  as  a  useful  urinary  antiseptic  in  the  later  stages 
and  chronic  forms  of  gonorrhoea.  It  may  be  used  as  a  prophylactic 
against  infection  in  case  of  operations  or  instrumental  manipulation 
of  the  genitourinary  tract.  Dosage. — 0-6  to  1  gramme  (10  to  15 
grains). 
HOLOCAINE  HYDROCHLORIDE.  ETHENYL-PARADIETHOXY-DIPHENYL- 
AMIDINE  HYDROCHLORIDE. 
Holocaine  hydrochloride,  CH3.C(  :  N.C6H4.OC2H5)(.NH.C6H4  OC2 
H5).HC1  ===  QgH^NoCXHCl,  is  the  hydrochloride  of  a  basic  conden- 
sation product  of  paraphenetidin  and  acetparaphenetidin  (phena- 
cetiri). 
Actions  and  Uses. — It  is  a  local  anesthetic  like  cocaine,  but  hav- 
ing the  advantage  of  quicker  effect  and  an  antiseptic  action.  Five 
minims  of  a  I  per  cent,  solution  when  instilled  into  the  eye  are 
usually  sufficient  to  cause  anesthesia  in  from  1  to  10  minutes.  It  is 
more  toxic  than  cocaine  and  without  effect  on  the  pupil  or  blood 
vessels.  It  is  not  so  useful  as  cocaine  when  the  vaso-constrictor 
effect  of  the  latter  is  desired.  It  is  said  not  to  cause  the  scaliness  of 
the  cornea  which  sometimes  results  after  the  use  of  the  older 
remedy.    Dosage. — It  is  applied  in  a  I  per  cent,  aqueous  solution 
1  This  is  the  chemical  name  for  a  preparation  on  the  market  under  the  names 
of  helmitol  and  urotropin,  new. 
