Am.  Jour.  Pharm. 
May.  1908. 
Hyoscyamus  Muticus, 
203 
per  cent,  hydrochloric  acid.  To  the  latter  solution  a  slight  excess 
of  ammonia  was  added  and  the  alkaloid  shaken  out  with  chloroform. 
After  evaporating  the  solvent  in  vacuo,  about  26  grammes  (065 
per  cent.)  of  slightly  colored  crystalline  alkaloid  was  obtained. 
A  portion  of  the  alkaloid  was  dissolved  in  acidulated  water  and 
the  alkaloid  fractionally  precipitated  with  auric  chloride.  Six  frac- 
tions were  obtained,  each  fraction  was  then  dissolved  in  hot  acidu- 
lated water  and  fractionally  crystallized;  three  fractions  were  obtained 
from  each  fractional  precipitate,  or  eighteen  fractions  in  all.  The 
aurichlorides  thus  obtained  were  dried  at  about  100°  C.  and  their 
melting  points  determined,  with  the  following  results  : 
MKIvTING  POINTS -OF  AURICHLORIDE  FRACTIONS. 
No.  1  No.  2  No.  3 
Fractional  precipitates        157-5°  C.  1610  C.  1610  C. 
Fractions  obtained  by 
crystallization  160.    157.5  158*5    161*    i6[.5  i6r     161.    161*5  160*5 
No.  4  No.  5  No,  6 
Fractional  precipitates        161*5°  C.  161*5  C.  160*5°  C. 
Fractions  obtained  by 
crystallization  160.    161*5  160*5    162*    162'    i6t*      161*5  161*  160*5 
Maximum  M.  P  ,  162°  C. 
Minimum  "  "   157*5°  C. 
The  following  are  the  melting  points  of  the  three  principal  my- 
driatic aurichlorides: 
Melting  Point. 
Atropine  aurichloride  136°  to  138°  C. 
Hyoscyamine  "   159°  to  162°  C. 
Hyoscine   197 0  to  199°  C. 
A  portion  of  the  alkaloid  was  dissolved  in  2  per  cent,  hydrochloric 
acid  and  treated  with  purified  animal  charcoal.  The  mixture  was 
then  filtered,  the  filtrate  made  slightly  alkaline  with  ammonia  and 
shaken  out  with  chloroform.  The  chloroformic  solution  was  eva- 
porated in  vacuo,  and  the  residual  alkaloid,  which  was  almost  white, 
dried  at  about  95 0  C.  The  alkaloid  thus  obtained  had  the  following 
characteristics: 
