AmMa?,riM8.anu*}    Liquor  Cresolis  Compositus,  U.S.P.  215 
(17)  Liquor  cresolis  compositus  (by  modified  process). 
(18)  Liquor  cresolis  compositus,  with  excess  of  1  per  cent,  of 
KOH. 
(19)  Liquor  cresolis  compositus,  with  excess  of  3  per  cent,  of 
KOH. 
(20)  Cresol  U.  S.  P.  and  glycerin,  equal  parts. 
(21)  Liquor  cresolis  compositus  from  metacresol. 
(22)  Liquor  cresolis  compositus,  with  excess  of  5  per  cent,  of 
KOH. 
(23)  Liquor  cresolis  compositus  from  orthocresol. 
(24)  Three  per  cent,  solution  of  phenol. 
It  will  be  noticed  that  a  preparation  containing  8  per  cent,  of 
soap  and  50  per  cent,  of  cresol  is  more  caustic  and  escharotic  than 
pure  cresol ;  probably  due  to  the  fact  that  the  cresol  is  rendered 
soluble,  and  the  skin  softer  and  therefore  more  easily  attacked  by 
the  cresol. 
A  preparation  containing  four-fifths  of  the  required  amount  of 
soap  produced  a  decided  redness  of  the  skin,  later  causing  it  to  peel 
off ;  while  the  U.S.P.  product  made  by  the  modified  process  pro- 
duced no  irritation.  It  is  important  that  saponification  be  complete, 
as  the  preparation  will  otherwise  be  irritating. 
According  to  Dr.  Otto  Heiler,  soap  increases  the  germicidal 
power  of  phenol  and  cresol  by  about  25  per  cent,  if  present  volume 
for  volume.    (Proc.  A.P.A.,  vol.  52,  p.  563.) 
The  above  facts  tend  to  show  that  the  proportion  of  soap  present 
in  the  U.S.P.  product  should  not  be  reduced. 
This  brings  us  back  to  the  original  formula,  which,  with  the  fol- 
lowing modification  in  the  working  directions,  is  the  best  that  can 
be  produced  at  present. 
COMPOUND  SOLUTION  OF  CRESOL. 
Cresol  500  gms. 
Linseed  oil  350  " 
Potassium  hydroxide   80  " 
Alcohol     35  c.c. 
Water,  a  sufficient  quantity  to  make  1000  gms. 
Dissolve  the  potassium  hydroxide  in  50  grammes  of  water  in  a 
tared  dish,  add  the  linseed  oil  and  mix  thorougly.  Heat  on  a  water 
bath  or  on  a  steam  bath  to  about  yo°  C,  incorporate  the  alcohol, 
