AmjuOi?y'i908.arm'}    Elixirs  of  the  National  Formulary.  337 
glycerite.  Even  a  larger  amount  of  glycerin,  however,  would  aid 
solution. 
Anise. — The  formula  is  very  unsatisfactory.  The  odor  is  not  that 
of  anise,  but  strongly  of  bitter  almond,  and  considerable  oil  separates, 
making  an  unsightly  preparation.  While  the  separation  of  oil  is 
recognized  by  the  "  Note  "  in  the  N.F.,  there  can  be  no  reason  for 
the  excess. 
Caffeine. — It  was  entirely  impossible  to  dissolve  the  caffeine  in 
the  125  c.c.  of  aromatic  elixir  directed.  Experiments  show  that  625 
c.c.  is  sufficient  and  a  change  should  be  made  in  the  directions. 
Calcium  Hypophosphite. — The  salt  dissolves  very  slowly,  a  small 
portion  remaining  undissolved.  It  is  doubtless  the  fault  of  the  salt, 
yet  it  seems  to  be  impossible  to  buy  an  article  which  is  wholly 
soluble.  One  worker  has  suggested  the  solution  of  a  freshly  pre- 
cipitated salt  to  avoid  the  difficulty. 
Calcium  Lactophosphate. — The  directions  are  faulty.  When  the 
calcium  lactate  was  rubbed  with  the  phosphoric  acid,  water  and 
syrup,  it  would  not  dissolve ;  but  when  first  dissolved  in  the  phos- 
phoric acid  and  then  mixed  with  the  other  ingredients,  no  difficulty 
was  encountered. 
Compound  Cathartic. — Considerable  sediment  separates  from  this 
elixir  after  standing  a  few  weeks.  This  criticism  applies  to  most  of 
the  elixirs  made  from  fluidextracts,  including  :  coca,  aromatic  erio- 
dictyon,  euonymus,  frangula,  grindelia,  cascara  sagrada,  and  com- 
pound taraxacum. 
Cinchona. — In  this  era  of  correct  titles,  this  elixir  can  hardly  be 
called  "  cinchona,"  since  it  is  made  from  cinchona  alkaloids  and 
artificially  colored.  The  preparation  is  very  satisfactory  from  a 
pharmaceutical  standpoint. 
Cinchona  and  Hypophosphites. — The  hypophosphites,  at  least  the 
calcium  hypophosphite,  dissolved  with  great  difficulty.  The  color 
is  considerably  lighter  than  the  "  elixir  of  cinchona."  The  acid  may 
be  responsible  for  this  color  change. 
Cinchona,  Iron  and  Pepsin. — This  preparation  develops  a  slight 
white  precipitate,  as  do  also  the  several  other  elixirs  containing  pep- 
sin, i.  e.t  cinchona,  pepsin  and  strychnine;  plain  pepsin;  pepsin, 
bismuth  and  strychnine  ;  pepsin  and  bismuth  ;  pepsin  and  iron. 
Coca. — After  a  few  days  the  elixir  became  cloudy,  talc  was  added 
and  the  preparation  again  filtered.  The  elixir  has  again  become 
cloudy. 
