35^ 
Beefy  Wine  and  Iron. 
f  Am.  Jour.  Pharm. 
I     August,  1908. 
quality  of  sherry  wine  and  meat  extract  used.  Furthermore,  it  is 
well  known  that  many  pharmacists  at  present  substitute  citrate  of 
iron  and  ammonia  for  the  tincture  of  citro-chloride  of  iron  because 
of  its  greater  solubility,  and  it  was  clear  that  the  iron  salt  used 
would  influence  the  quantity  of  iron  present  in  the  preparation. 
Five  mixtures  were  prepared,  as  follows : 
No.  i.  High-grade  meat  extract  corresponding  to  Liebig's  ex- 
tract ;  tincture  of  citro-chloride  of  iron ;  all  materials  used  in  the 
exact  proportions  directed  by  the  Formulary ;  alcohol  not  removed 
by  distillation  ;  solution  not  filtered. 
No.  2.  Half  of  No.  I  was  filtered  and  the  original  volume  restored 
by  the  addition  of  sherry  wine. 
No.  3.  The  same  as  No.  1,  except  that  an  equivalent  amount  of 
iron  in  the  form  of  citrate  of  iron  and  ammonia  was  used;  alcohol 
not  removed ;  solution  not  filtered. 
No.  4.  Half  of  No.  3  was  filtered  and  the  original  volume  restored 
by  the  addition  of  sherry  wine. 
No.  5.  Lower-grade  meat  extract,  but  with  the  quantity  suffi- 
ciently increased  to  supply  the  same  amount  of  nitrogen  as  33 
grammes  of  Liebig's  extract ;  the  exact  procedure  of  the  Formulary 
was  followed,  using  the  tincture  of  iron,  and  including  the  removal 
of  the  alcohol  by  distillation,  and  the  double  filtration ;  the  sherry 
used  was  different  from  that  used  in  the  other  four  mixtures. 
The  analysis  of  the  five  preparations  and  a  partial  analysis  of  the 
sherry  are  shown  in  the  following  table: 
PRE!  PARATION. 
a.*-  _ 
tcO  as 
Alcohol, 
by  Vol. 
Extract. 
Ash. 
Iron 
(Fe) 
Total 
Nitrogen 
Nitrogen 
as  Am- 
monia. 
No.  1. 
High-grade  extract ;  tiuc- 
ture  of  iron  ;  not  filtered, 
1*02165 
Per  ct. 
27-18 
Per  ct. 
14-12 
Per  ct. 
i*ii3 
Per  ct. 
0-123 
Perct. 
0-250 
Per  ct. 
0*007 
No.  2. 
High-grade  extract ;  tinc- 
ture of  iron;  filtered    .  . 
101562 
26-20 
12-36 
0-723 
O'OII 
0-178 
0*007 
No.  3. 
High-grade    extract  ;  ci- 
trate of  iron  ;  not  filtered, 
1*02660 
23-82 
14-09 
1-138 
0-I2I 
0-295 
0*066 
No.  4. 
High-grade    extract  ;  ci- 
trate of  iron  ;  filtered  .  . 
1*02564 
24'12 
I3'94 
1-162 
OT07 
0-278 
0*064 
No.  5. 
Low-grade  extract ;  tinc- 
ture of  iron  ;  filtered    .  . 
1 '02654 
19-50 
12-95 
1-401 
0*024 
0-216 
0*009 
Sherry  used  in  Nos.  i  to  4  .... 
o-  99602 
2I-50 
5"53 
Sherry 
used  in  No.  5  
0-99939 
22-75 
675 
