Am.  Jour.  Pharm.  \ 
November,  1908.  j 
Chloroform  in  Logenges. 
513 
There  is  a  slight  loss  which,  however,  is  not  likely  to  occur  when 
a  lozenge  is  under  examination,  as  the  latter  dissolves  slowly,  liberat- 
ing the  chloroform  gradually. 
The  lozenges  must  not  be  powdered,  but  a  whole  or  half  lozenge 
used.  When  a  chloroform  lozenge  is  powdered,  even  coarsely,  a 
large  proportion  of  the  chloroform  is  lost  in  a  few  minutes,  as  will 
be  seen  from  the  following  results : 
Chloroform 
Lozenge,  not  powdered   3. 12% 
Powdered  lozenge  weighed  a  few  minutes  after  powdering.  1.52% 
To  obtain  a  correct  estimate  of  the  chloroform  present,  two  or 
three  determinations  should  be  made  and  the  mean  taken. 
Lozenges  containing  up  to  3  per  cent,  of  chloroform  do  not  vary 
much,  but  over  that  figure  variation  is  likely.  But  even  in  the  latter 
case,  if  the  chloroform  is  determined  in  two  sets  of  duplicates,  the 
mean  of  each  will  be  in  fair  accordance,  as  will  be  seen  by  the 
following  example : 
Minims  CHC13 
Chloroform.  Average.  per  lozenge.  Average. 
la.     5-28%^  T  1 
2a.  6.44% 
5-86%  \]£l\ 
1 1 0  0  ) 
O  L  r  8/^07  1  00  (  T JLJL 
2b.  5.88%;        5'b5^  iTvU 
10  0 
1  2 
TOO" 
No  two  lozenges  are  likely  to  contain  exactly  the  same  percentage 
of  chloroform,  although  sometimes  the  results  are  almost  identical. 
Lozenges  containing  licorice  give  dark  colored  solutions  on  boiling 
with  alkali ;  this  does  not  affect  the  titration,  as  the  treatment  with 
nitric  acid  and  calcium  carbonate  decolorizes  the  liquid. 
In  the  following  table  are  recorded  the  results  obtained  in  the 
examination  of  nine  samples  of  chloroform  lozenges.  Each  sample 
was  tested  in  duplicate,  the  results  represent  the  mean : 
No. 
Average  weight 
Chloroform 
Minims  of  chloroform 
of  lozenge. 
per  cent. 
in  each  lozenge. 
I. 
9.2  grains 
3-40 
TTO 
2. 
23 
3.12 
51 
Too" 
3- 
32 
I.02 
2  3 
Too 
4- 
28 
5.86 
T    1  6 
1To~o 
5- 
37 
2.56 
6  7 
1  0  0 
6. 
30 
2-53 
5  4 
To~o 
7- 
24-5  " 
5:08 
8  8 
TOO 
8: 
43 
I.90 
5  8 
Too" 
9- 
28 
I.72 
34 
TOO" 
