5  H 
Chloroform  in  Lozenges. 
jAm  Jour.  Pharm. 
'/  November,  1908. 
The  percentage  of  chloroform  may  be  converted  into  minims  per 
lozenge  by  the  following  formula : 
C  X  7104  X  L 
100 
C  =  per  cent.  CHC13. 
L  =  average  weight  of  lozenge. 
Chloroform  lozenges  vary  in  their  keeping  qualities.  Two  sam- 
ples were  kept  in  card-board  boxes  at  room  temperature  for  one 
month,  with  the  following  results : 
Ch'oroform  minims 
Chloroform.  per  lozenge. 
Average  weight    Before      After  one    Before   After  one 
of  lozenge.        aging.        month.      aging.  month. 
No.  i.     White  lozenge      37  grains    1.11%    0.15%    ffo  tw 
No.  2.     Brown  lozenge    )  •  ~  ~      23      2  2 
contains  licorice  I  29  gmmS    I,I3/o     l'10'0    Too  too 
Lozenges  containing  licorice  extract  appear  to  hold  chloroform 
better  than  a  plain  sugar  base,  the  extractive  renders  the  base 
impermeable.  A  well-made  chloroform  and  licorice  lozenge  may 
be  heated  for  some  time  at  ioo°  C,  and  still  retain  a  considerable 
proportion  of  chloroform.    The  following  results  illustrate  this : 
Chloroform.  Chloroform  minims 
Average  weight  Before  After  heating  per  lozenge 
of  lozenge.  heating.       to  ioo°  C  for  i  hr.      Before.  After. 
9.2  grains  3.4%  i-33%  t¥o  tto 
The  average  loss  of  chloroform  in  the  process  of  manufacture 
appears  to  be  about  50  per  cent. 
Analytical  Department, 
Parke,  Davis  &  Co. 
