528  Fluid gly cerates.  \  A£- Jou/ 
^  &  J  \   November,  1908. 
The  following  has  been  adopted  as  a  general  formula  or  type 
and  is  referred  to  in  this  paper  as  the  "  type  process  "  so  as  to  avoid 
useless  repetition.  It  is  stated  in  terms  for  100  c.c.  of  finished 
product,  the  quantity  being  that  used  in  each  of  the  numerous  experi- 
ments tried. 
Take  of  the  drug  in  coarse  powder  100  Gm. 
Glycerin   50  c.c. 
Distilled  water  150  c.c. 
Chloroform  water  a  sufficient  quantity  to  make  of  finished 
•product   100  c.c. 
Mix  the  glycerin  and  distilled  water  and  moisten  the  drug  thor- 
oughly with  sufficient  of  the  mixture,  and  then  pack  it  very  lightly 
in  a  cylindrical  percolator  and  saturate  thoroughly  with  menstruum, 
cork  up  and  cover  the  percolator  and  allow  to  macerate  for  two 
days,  then  continue  to  percolate  till  the  drug  is  exhausted,  using  first 
the  remainder  of  the  menstruum  and  then  chloroform  wTater.  Re- 
serve the  first  50  c.c.  of  percolate  and  set  this  aside.  Evaporate  the 
remaining  percolate  on  a  water  bath,  the  weaker  portion  first,  then 
the  stronger  till  reduced  to  60  c.c,  and  then  add  the  reserve  and 
continue  the  evaporation  till  the  product  measures  100  c.c.  If 
evaporation  has  been  carried  too  far,  make  up  to  100  c.c.  with  dis- 
tilled water.  Set  the  product  aside  for  several  days  to  settle,  decant 
the  clear  supernatant  layer  and  strain  the  remainder  through  muslin. 
For  some  of  the  alkaloidal  drugs  the  addition  of  an  acid  to  the 
menstruum  to  insure  extraction  was  deemed  essential  and  in  these 
the  same  acid  was  not  used  throughout  but  a  selection  was  made 
that  in  each  case  appeared  to  be  the  most  appropriate  to  insure 
extraction  with  the  least  amount  of  decomposition  of  the  alkaloids. 
In  the  selection  of  the  acids  the  writer  has  quite  likely  erred  ir 
judgment  at  times.  In  a  few  other  drugs,  such  as  glycyrrhiza  and 
senega,  the  addition  of  an  alkali  was  deemed  necessary  and  these 
additions  are  all  detailed  in  the  formulas. 
Unless  otherwise  specified,  the  acid  or  alkali  was  added  to  the 
portion  of  the  glycerin-water  menstruum  used  to  moisten  the  drug. 
In  the  July  issue  of  Merck's  Report 2  appeared  the  reprint  of  an 
2  Merck's  Report,  179  (July,  1908). 
