Am.  Jour.  Pharm. ) 
XoTember,  1908.  j 
Fluidgly  cerates. 
537 
The  product  deposited  a  scanty  sediment  and  after  straining  this 
off,  it  remained  clear  and  bright.  It  is  red-brown  in  color  with  an 
acidulous  and  characteristic  bitter  taste  and  well  represents  the 
activity  of  the  drug.  It  mixes  slightly  cloudy  with  water  or  diluted 
alcohol  and  clear  with  syrup,  but  turbid  with  alcohol.  Assayed  by 
the  official  method  for  the  assay  of  Fluidextract  of  Colchicum  Seed 
it  gave  0.36  Gra.  of  colchicine  in  100  c.c. 
Fluidglycerate  oe  Colocyxth. 
Take  of  Colocynth  in  number  30  powder  100  Gm. 
Proceed  according  to  the  type  process,  using  90  c.c.  of  the 
glycerol-water  menstruum  to  moisten  the  drug. 
This  product  deposited  a  heavy  albuminous  precipitate  and 
although  the  strained  liquid  has  remained  clear,  the  marc  shows 
that  the  drug  has  not  been  exhausted,  and  I  do  not  consider  it  satis- 
factory. The  addition  of  an  alkali  may  be  necessary  to  the  glycerol- 
water  menstruum  in  order  to  make  it  a  satisfactory  medium. 
Fluidglycerate  of  Conium. 
Take  of  Conium  in  number  30  powder  100  Gm. 
Acetic  Acid   5  c.c. 
Mix  the  acetic  acid  with  45  c.c.  of  the  glycerol-water  menstruum 
and  moisten  the  drug  with  the  mixture,  and  then  proceed  according 
to  the  type  process. 
An  albuminous  sediment  formed  at  once  on  heating.  This  was 
allowed  to  settle  in  the  product  and  then  gotten  rid  of  by  decantation 
and  straining-.  The  preparation  has  since  remained  clear  and  pos- 
sesses the  odor  and  taste  of  the  drug.  It  mixes  clear  with  syrup, 
slightly  cloudy  with  water,  more  so  with  diluted  alcohol  and  quite 
turbid  with  alcohol.  Assayed  by  the  official  process  for  assay  of 
Fluidextract  of  Conium  it  yielded  0.466  Gm.  of  coniine  in  100  c.c. 
Two  other  samples  were  made  from  the  same  conium  in  the  one 
using  10  c.c.  of  acetic  acid  and  the  other  no  acid.  The  former 
assayed  0.408  and  the  latter  0.120  Gm.  of  coniine.  From  these  ex- 
periments, we  are  justified  in  concluding  that  an  acid  is  essential  to 
the  extraction  of  conium  but  that  a  quantity  in  excess  of  that 
directed  is  not  advisable. 
