Am.  Jour.  Pharm.  ) 
April,  1910.  / 
Alkaloids  of  Cinchona  Bark. 
175 
Malabar  and  Mysore  (Ceylon)  seeds  and  reports  that  there  was 
practically  no  difference,  the  result  being: 
The  wild  Ceylon  cardamom  is  not  an  article  of  importance  nor 
does  it  enter  commerce  in  any  large  amount.  In  the  communication 
above  Messrs.  Stafford  Allen  &  Sons  state  that  their  experiment  with 
distilling  the  oil  from  wild  seed  was  unsatisfactory  and  they  use  only 
the  cultivated  Ceylon  seed  for  their  product,  and  this  is  also  undoubt- 
edly the  practice  of  the  other  manufacturers.  None  of  the  oils 
examined  showed  results  comparable  with  the  data  reported  for  wild 
Ceylon  cardamom  oil.  On  the  other  hand,  the  reports  of  Parry, 
Allen,  Dodge,  and  Chiris  as  well  as  my  own  limited  examinations 
all  confirm  the  statement  that  the  oil  now  on  the  market  is  distilled 
from  the  fruit  of  Elettaria  Cardamomum  and  that  the  statement  of 
Gildemeister  and  Hoffmann  in  this  respect  needs  correction. 
SOLUBILITY  OF  ALKALOIDS  OF  CINCHONA  BARK  AND 
THEIR  SALTS  IN  WATER  AT  A  TEMPERATURE 
OF  250  C. 
At  the  request  of  the  editor  of  the  Journal  I  submit  a  list  of 
cinchona  alkaloids  and  salts  of  which  the  solubility  in  water  at  a 
temperature  of  25 0  C.  has  been  determined. 
I  desire  to-  call  attention  to  the  fact,  that  some  of  these  salts 
are  partly  decomposed  by  water  into  a  more  soluble  and  a  less  soluble 
compound,  which  property,  no  doubt,  has  caused  many  of  the  dis- 
crepancies in  previous  determinations,  carried  out  in  different  ways. 
For  instance,  1  part  of  a  pure  basic  salt  of  quinine  glycerophosphate 
of  the  formula  (C20H24N2O2)2PO4H2.CsH7O2  +  5H20  requires  for 
complete  solution  about  850  parts  of  water  of  25 0  C.  If,  however, 
a  large  excess  of  this  salt  is  treated  with  water  of  25 0  C.  for  several 
hours  and  frequently  shaken,  the  solution  filtered  off  from  the  undis- 
Oil  of  Malabar  cardamoms 
Oil  of  Mysore  cardamoms . 
Sp.  gr.  at 
1S.S0  C. 
O.9418 
O.9418 
Opcical  Rotation  at 
6°  C.  (100  mm.  tube). 
+  40°  41' 
+  46°  39' 
By  George  L.  Schaefer. 
