Am.  Jour.  Pharni. 
May,  1910. 
Quinine  Salts. 
219 
QUININE  HYDROBROMIDE. 
Lines  21  and  22  of  the  U.  S.  P.  description  of  this  salt  read: 
"  Ammonia  water  added  to  an  aqueous  solution  of  the  salt  produces 
a  white  precipitate,  which  is  soluble  in  a  large  excess  of  the  re- 
agent." This  test  cannot  be  carried  out,  except  with  very  small 
traces  of  the  salt,  and  ought  to  be  omitted. 
In  view  of  this  I  would  suggest  the  following  modification  of 
this  test  and  its  adoption  for  all  the  quinine  salts :  "  Ammonia 
water  added  to  an  aqueous  solution  of  the  salt  produces  a  white 
precipitate,  which  is  easily  soluble  in  ether."  This  would  differen- 
tiate the  quinine  salts  at  once  from  the  salts  of  other  cinchona 
alkaloids. 
The  solubility  in  ether  of  this  salt  is,  according  to  the  U.  S.  P. 
1  to  16,  while  it  is  practically  insoluble  or  very  difficultly  soluble, 
requiring  about  700  parts  of  the  solvent  for  solution. 
QUININE  HYDROCHLORIDE. 
According  to  the  U.  S.  P.,  sulphuric  acid  should  not  produce  a 
color  with  this  salt.  However,  if  the  salt  is  treated  with  concen- 
trated sulphuric  acid  the  resulting  solution  is  yellowish,  hydrochloric 
acid  gas  being  developed. 
When  slowly  heated  it  melts  at  about  120°  C.  with  its  full 
amount  of  water  of  crystallization.  The  commercial  salt  containing 
1-2  per  cent,  less  water  melts  at  about  1250  C.  The  completely 
anhydrous  salt  melts  at  about  1 5 5-1 60 0  C.  The  latter  quickly  ab- 
sorbs water  from  the  air,  again  lowering  the  melting  point. 
There  is  no  distinct  melting  point  for  the  commercial  salt,  accord- 
ing to>  the  larger  or  smaller  percentage  of  water  of  crystallization 
in  the  salt,  the  melting  point  differing  from  5-100  C. 
The  salt  is  not  soluble  in  ether  in  the  proportion  of  1  to  240, 
but  it  is  almost  insoluble  or  very  difficultly  soluble  in  ether,  requir- 
ing about  1000  parts  of  the  solvent. 
QUININE  SALICYLATE. 
Solubility  in  water  at  250  C  1:  2100 
Solubility  in  water  at  80 0  C  1  :  280 
Solubility  in  alcohol  at  25 0  C  1:23 
Solubility  in  alcohol  at  6o°  C  1:5 
Solubility  in  ether,  about  1  :  780 
Solubility  in  chloroform  1:10 
