Am.  Jour.  Pharm.  ) 
October,  1910.  j 
Pharmazeutischen  Institut. 
489 
Zernik  claims  that  p-brombenzoic  acid  is  only  a  mechanically 
mixed  ingredient  in  eulatin,  and  that  it  is  hard  to  believe  that 
o-amidobenzoic  acid  is  chemically  bound  to  the  antipyrine.  At  least 
the  following  experiment  is  evidence  against  it.  If  eulatin  is  ex- 
tracted with  cold,  absolute  ether,  p-brombenzoic  acid,  o-amidoben- 
zoic acid,  and  antipyrine  go  into  solution.  If  the  ethereal  solution 
is  shaken  out  with  cold  water  the  antipyrine  is  obtained,  while  the 
acids  remain  in  solution  in  the  ether. 
It  was  further  ascertained  that  when  eulatin  is  subjected  to  a 
temperature  of  ioo°  it  loses  by  weight  0.56  per  cent.,  and  when 
shaken  out  with  chloroform  50.94  per  cent,  antipyrine  is  separated. 
As  a  result  of  his  calculations  he  states  that  it  is  a  mixture  of  two 
parts  of  p-brombenzoic  acid  and  antipyrine  in  molecular  propor- 
tions and  one  part  o-amidobenzoic  acid  and  antipyrine,  also  in 
molecular  proportions.  He  says  that  it  is  impossible  to  determine 
by  analytical  means  just  how  this  mixture  is  brought  about.  The 
declaration  that  eulatin  is  "  amidobrombenzoesaures  antipyrine " 
he  states  to  be  untrue  according  to  his  investigation. 
Physicians  should  be  very  careful,  he  advises,  in  accepting 
recommendations  and  testimonials  of  the  many  preparations  of 
supposedly  newer  composition  on  the  market. 
Meligrin. — The  makers  of  this  product  give  no  information  as  to 
its  true  nature.  A  microscopical  and  chemical  investigation  by 
Zernik  of  the  contents  of  an  original  package  bought  on  the  open 
market  showed  it  to  be  a  mixture  of  86  parts  of  antipyrine  and  14 
parts  of  methyiacetanilid  (exaligin). 
It  is  a  white  crystalline  powder,  very  soluble  in  water,  with  the 
bitter  taste  characteristic  of  antipyrine. 
The  manufacturers  of  this  remedy  have  taken  advantage  of  the 
fact  that  antipyrine  (like  sodium  salicylate,  chloral,  etc.)  increases 
the  solubility  in  water  of  many  organic  substances. 
Mergandol  is  the  name  given  to  a  liquid  preparation  recom- 
mended for  intramuscular  injection  for  the  treatment  of  syphilis 
and  also  for  external  application  on  the  skin  eruptions  of  the  same 
disease. 
The  manufacturers  state  that  it  is  a  solution  of  hydrargyrum- 
natriumglyceratum  in  glycerin,  each  cubic  centimetre  containing 
0.0035  Pure  mercury. 
Zernik  says  that  while  sodium  glycerate  is  mentioned  in  chemical 
literature,  mercury  or  mercury-sodium  glycerate  is  unknown. 
