MANUFACTURE  OP  SULPHATE  OF  QUININE. 
455 
Jobst  of  Germany  has  not  rejected  the  New  Granada  barks, 
nor  can  quinine,  containing  a  certain  percentage  of  quinine,  be 
admitted  into  the  United  States.  Foreign  quinine  rejected  at 
New  York  has  been  on  sale  in  the  London  market  this  spring. 
Quinine  if  intended  to  pass  as  quinine,  must  be  pure. 
There  ought  to  be  no  question  about  the  use  of  New  Granada 
barks  for  the  manufacture  of  quinine.  Has  tbere  ever  been  an 
objection  to  the  use  of  Carabaya  bark  ?  As  Mr.  Howard  says, 
"  The  quinine  contained  in  them  is  identical  in  all,  from  whatever 
species  obtained."  The  monopoly  of  Bolivian  bark  has  proved 
an  universal  blessing,  by  stimulating  the  importation  of  other 
kinds.  What  would  have  been  the  price  of  quinine  if  manufac- 
turers had  depended  solely  on  the  use  of  Bolivian  bark  ? 
We  imported  last  year  17,000  serons  of  New  Granada,  and 
1500  serons  of  Bolivian.  The  New  Granada  all  sold  ;  but  the 
Bolivian,  being  held  for  a  monopoly  price,  is  still  in  the  market, 
proving  that  this  kind  has  very  little  demand. 
Delondre,  in  his  new  work  on  quinine  barks,  gives  an  analysis 
of  a  New  Granada  bark  containing  quite  as  much  quinine  as  Bo- 
livian Calisaya.  If  the  Calisaya  of  Santa  Fe  or  Fusagasuga  and 
Pitaya  barks  of  New  Granada  had  been  introduced  into  the 
market  before  the  Bolivian,  there  would  be  no  question  about  the 
quality  of  the  alkaloids  they  yield. 
I  am,  yours  obediently,  W.  H.  Cole. 
16  George  Street,  Mansion  House. 
PharmaceuticalJournal,  July,  1854. 
MANUFACTURE  OF  SULPHATE  OF  QUININE. 
Messrs.  Thivaites'  and  Her apatli  s  Patent  (Enrolled  May 15th, 
1854.) — The  process  is  as  follows : — 112  lbs.  of  coarsely  powdered 
Peruvian  bark  are  first  boiled  for  one  hour  or  more  in  a  solution 
of  carbonate  of  soda,  made  by  dissolving  28  lbs.  of  the  carbonate 
in  56  gallons  of  water ;  the  effect  of  this  preliminary  process  is 
to  remove  much  of  the  useless  coloring  and  extractive  matter  of 
the  bark.  The  bark  is  afterwards  pressed,  then  thrown  into  a 
vat  or  tub,  and  well  agitated  with  cold  water ;  by  this  means, 
more  of  the  coloring  and  extractive  matter  is  removed.  The 
bark  is  then  collected  on  a  strainer  and  expressed  dry,  after 
