458 
MANUFACTURE  OF  SULPHATE  OF  QUININE. 
named  by  the  patentees,  to  the  extraction  of  veratria  and  other 
alkaloids. 
The  patentees  claim  the  use  of  fusel  oil,  camphene,  turpentine 
or  other  hydrocarbons  insoluble  in  water,  in  the  manner  described, 
for  separating  alkaloids  from  the  liquid  in  which  they  are  held 
in  suspension  or  solution. 
The  above  process  of  manufacturing  quinine  without  alcohol 
appears  to  be  similar  to  the  undermentioned  one. 
Messrs.  Pelletier  and  Despretzs  Process  for  the  Manufacture 
of  Sulphate  of  Quinine  (Patented  in  England,  July  25th,  1833.) 
The  principal  object  of  the  patentees  is  stated  by  them  to  be  the 
production  of  sulphate  of  quinine,  by  means  of  distilled  or  com- 
pressed oils,  whether  derivable  from  vegetable,  animal  or  mineral 
substances,  or  matter  as  a  substitute  for,  and  without  the  aid  of, 
alcohol.  They  then  describe  the  following  mode  of  obtaining 
sulphate  of  quinine  : — When  distilled  oil  is  intended  to  be  used, 
the  bark  having  been  treated  by  acids,  and  the  quinine  and  other 
matters  soluble  in  the  acid  having  been  precipitated  by  means  of 
lime,  in  the  usual  method  of  making  quinine,  the  calcareous  pre- 
cipitate is  dried  and  reduced  to  a  fine  powder ;  it  is  then  treated 
several  times  with  the  oil  intended  to  be  used,  in  suitable  vessels. 
The  patentees  prefer  the  use  of  oil  of  turpentine.  The  oil  is 
then  to  be  separated  by  decantation  or  filtration. 
When  expressed  oil  is  used,  care  must  be  taken  that  the  lime 
be  first  extracted,  otherwise  an  insoluble  lime  soap  would  be 
formed. 
The  precipitate  is  then  dissolved  in  an  acid,  and  the  rough 
quinine  precipitated  by  ammonia  ;  when  in  this  state,  it  is  treated 
with  oil  several  times  which  will  dissolve  the  quinine,  and  separate 
all  foreign  matters  therefrom. 
After  obtaining  the  quinine  in  solution  by  expressed  or  dis- 
tilled oils,  the  oil  is  treated  by  water  acidulated  with  any  acid 
capable  of  forming  a  salt  with  the  quinine  (preference  given  to 
hydrochloric  acid,)  the  acidulated  waters  separate  the  quinine 
from  the  oil,  the  separation  being  easily  effected  by  decantation, 
as  the  two  liquids,  having  different  specific  weights,  will  not  com- 
bine. The  quinine  thus  dissolved  is  precipitated  by  an  alkali,  and 
after  that  it  is  reduced  to  sulphate  by  uniting  it  to  sulphuric  acid, 
care  being  taken  to  effect  a  complete  saturation,  and  decolorize 
