REMARKS  ON  MONSEL'S  PERSULPHATE  OF  IRON.  403 
disappear  under  its  use*  the  child  at  the  same  time  improving  in 
health  generally,  and  no  untoward  symptoms  arising  on  the  dis- 
appearance of  the  dermal  inflammation.  I  have  used  it  suspended 
in  simple  syrup  on  the  glycerole  of  the  hypophosphites,  giving 
to  a  child  under  five  years  of  age  from  2  to  5  grains  thrice  daily. 
Children  take  it  without  disgust  or  loathing. 
I  have  thus  hastily  answered  your  inquiry,  and  remain, 
Yours,  respectfully, 
J.  C.  Hupp,  M.  D. 
REMARKS  ON  MONSEL'S  PERSULPHATE  OF  IRON. 
Br  William  Procter^  Jr. 
M.  Monsel,  whose  name  attaches  to  this  preparation,  is  at  pre- 
sent in  the  position  of  Pharmacien  Major  in  the  French  service. 
In  1852,  whilst  attached  to  the  medical  corps  of  the  French  army 
at  Rome,  he  published,  in  a  letter  dated  Oct.  13th,  of  that  year, 
the  fact  that  persulphate  of  iron  was  the  most  powerful  haemos- 
tatic among  the  agents  then  known,  and  he  has  the  credit  of 
having  first  noticed  this  property  of  the  salt. 
When  Pharmacien  Aid-major,  at  the  Military  Hospital  of 
Bordeaux,  M.  Monsel  published  an  essay  in  the  Bulletin  de 
Theraputique,  which  M.  Soubeiran  republished  in  the  Journal  de 
Pharmacie  et  de  Chimie,  page  208,  Sept.  1857,  with  a  note  of 
approval.  The  following  is  Monsel's  process  and  comments  as 
there  detailed : — 
"  Take  of  distilled  water  100  grammes, 
Sulphuric  acid  (60°  B.)  10  grammes.  / 
Heat  the  mixture  to  ebullition  in  a  porcelain  capsule  capable 
of  holding  a  pint,  and  add : — 
Protosulphate  of  iron,  50  grammes, 
After  the  solution  is  completed,  throw  into  the  boiling  liquid, 
little  by  little  :— 
Nitric  acid  (35°  B.)        16  grammes. 
When  the  violent  evolution  of  red  vapors  has  ceased,  add  in 
portions : — 
Protosulphate  of  iron,  pulverised,  50  grammes. 
The  solution  of  this  new  portion  of  sulphate  of  iron  disen- 
gages more  red  vapors.  Lastly  the  volume  is  completed  to  100 
