AmMa"'i889arm"}    Abstracts  from  the  French  Journals.  243 
will  soon  present  the  results  of  experiments  and  analyses  made  upon 
extracts  made  by  this  process.1 
Exalgine  or  orthomethylacetanilide. — Messrs.  Dujardin- 
Beaumetz  and  Bardet  find  that  the  effects  of  this  substance  bear 
a  strong  resemblance  to  those  obtained  from  antipyrine  ;  but  exalgine 
acts  more  decidedly  upon  the  sensibility  and  less  upon  the  nervous 
centres.  Therapeutically,  the  analgesic  effects  of  exalgine  may  be 
obtained  in  single  doses  of  25  cgm.  to  40  cgm  •  or,  from  40  cgm.  to  75 
cgm.  may  be  taken  daily  in  two  doses.  The  analgesic  action  appears  to 
be  superior  to  that  obtained  from  antipyrine,  even  in  all  forms  of  neu- 
ralgia, visceral  neuralgia  included.  We  have  not  observed,  say  the 
authors,  any  gastric  or  intestinal  irritation,  rash  or  cyanosis  as  follow- 
ing its  use.  Exalgine  is  eliminated  by  the  kidneys  and  diminishes 
the  amount  of  sugar  in  the  urine.  It  is  antiseptic,  antithermic  and 
analgesic,  the  latter  action  predominating.    Nouv.  Rem.,  March  24 
Salicylates  of  the  Cresols. — These  salts  may  be  prepared  from 
ortho,  meta  or  para  crejol  by  a  process  similar  to  that  used  in  the  mak- 
ing of  salol.  They  are  insoluble  in  water,  slightly  soluble  in  cold 
alcohol,  and  are  easily  crystallized.  M.  Nencki  states  that  they  de- 
compose in  the  economy,  where  they  exert  an  antiseptic  power  equal 
to  that  of  salol,  without  producing  toxic  effects.  M.  Sahli  is  quoted 
as  saying  :  "  When  a  considerable  dose  of  antiseptic  substance  is  to  be 
introduced  into  the  digestive  tract,  the  salicylates  of  ortho  or  para 
cresol  should  have  the  preference  over  salol."  The  same  writer  pre- 
fers these  salts  to  salol  in  articular  rheumatism  and  vesical  maladies. 
— Comptes  rend.,  Feb.  4 ;  R&pert.  de  Phar.,  March  10. 
Doses  of  Sulphonal. — In  a  long  study  of  sulphonal,  Bull.  gen. 
de  Therap.,  March  15,  M.  Egasse  gives  the  doses  as  follows  :  For 
children,  15  to  25  cgm.,  two  hours  before  bed-time.  For  women,  1 
to  2  gm.;  and  for  men,  2  to  5  gm.,  daily,  either  fractionally,  or,  as 
seems  preferable,  in  massive  doses,  given  during  a  meal,  or  two  hours 
before  the  hour  for  sleep.  It  is  best  given,  finely  pulverized,  in  cap- 
sules, but  may  be  held  for  some  time  in  suspension  in  dense  mucila- 
ginous mixtures.    It  may  also  be  given  in  wine  or  milk. 
1  The  process  of  preparing  extracts  by  cold  was  described  by  Professor  Alfon- 
so Herrera  of  Mexico,  in  Amer.  Jour.  Phar.  1877  pp.  437-440.  Mr.  Adrian's 
improvements  consist  in  the  use  of  a  centrifugal  apparatus  for  separating  the 
concentrated  solution  from  the  ice,  and  in  finally  evaporating  in  vacuo.  Prof. 
Herrera  propose  1  such  preparations  to  be  called  opopycnols. — Editor. 
