Am.  Jour.  Pharni. 
Nov.,  1889. 
The  Synthesis  of  Alkaloids. 
551 
fernientatives.  Since  that  publication  there  have  been  several  addi- 
tions to  the  list :  the  three  compounds,  ortho,  meta  and  para  cresyl 
salicylate,  prepared  by  Nencki,  the  discoverer  of  salol  and  betol,  to 
which  they  are  analogous ;  anisic  acid  (methylated  salicylic  acid)  and 
guiacol,  the  monomethyl  ether  of  pyrocatechin.  This  last  is  now 
advertised  as  "the  sovereign  remedy  in  pulmonary  tuberculosis." 
The  third  group  comprised  other  phenyl  deviatives  and  included : 
Acetophenone  (hy pnone)   C6H 5 .CO.CH 3 
Acetanilide,  or  phenyl -acetaniide  (anti  febrine) .C 6  H  5  .NH.C  2H  3  0 
Brom-acetanilide  C6H4Br.NH.C2H30 
Benzanilide  C6H5NH.C7H50. 
Acety  1-amidophenol  C  6  H  4  ( OH )  .NH.C2  H  3  0 
Para-acetphenetidine  f phenacetine)  C 6 H 4 ( OC 2 H  a )  N H .C 2 H 3 0 
Acetyl  phenyl-hydrazine  (pyrodine)  C6H5.N2H2(C2H30) 
Phenyl  hydrazine-levulinic  acid  (antithermine.C6H5N2H(CH3)C(CH2)2COCH 
Benzoyl  sulphinide  (saccharin)  C6H4^gQ  ^NH 
Their  therapeutic  character  is  somewhat  mixed,  but  in  general  they 
seem  to  be  antipyretics  and  sedatives.  To  this  list  has  since  been 
added :  Methyl  phenyl-acetamide,  or  methylated  antifebrin,  under 
the  trade  name  of  "  Exalgin,"  and  para  acetanisidin,  or  oxy-methy- 
lated  antifebrin,  known  commercially  as  "  Methacetin,"  while  what 
appeared  in  my  list  as  brom-acetanilide  is  now  introduced  as  bromated 
antifebrin,  or  commercially  as  "  Antisepsin  ; "  and  the  acetylphenyl-hy- 
drazine  known  at  first  under  the  trade  name  of  "  pyrodine,"  is  now 
"  Hydracetin." 
If  we  make  this  list  to  include  both  phenyl  and  naphthyl  deriva- 
tives outside  of  the  phenol  and  naphthol  class,  we  may  also  put  here 
tetrahydronaphthylamine,  which  has  recently  been  introduced  and 
claimed  to  have  value  as  a  new  mydriatic. 
The  fourth  group  comprised  pyrrol  and  pyrazol  derivatives,  and 
included  : 
Tetraiodo  pyrrol  (iodoD  C4HI4N. 
Diphenyl-m ethyl  pyrazol  C3(C6H5)2 (CH 3)HN2. 
Pheny  1-dimethyl-py razolon  (antipyr ine)  (C 6  H 5 )  (CH 3 )  2 C 3 HN 2 0. 
No  recent  additions  have  been  made  to  this  list. 
The  fifth  and  last  group  comprised  quinoline  derivatives,  and 
included  : 
Quinoline  CgH^ 
Methyl-tetrahydro-quinoline  sulphate  (M  Kair- 
oline)  C9H10TsT(CH3)H2S04 
