574 
Cupreine. 
A.m.  Jour.  Pharm. 
Nov..  1889. 
tions  of  varying  concentration  ;  it  was  found  that  its  value  increased 
with  the  dilution  of  the  solutions,  and  was  generally  somewhat  higher 
for  alcoholic  than  for  aqueous  solutions  of  the  same  strength.  The 
values  given  below  are  those  obtained  with  the  most  dilute  solutions 
used.    They  are  calculated  from  the  formula  [a]D—  Vx/lp.    In  the 
FORMULA. 
3(C19H22N202),H20  
C19H22N202,HC1+,H20. 
C19H22N202,2HC1 
+H20. 
C19H22N202,HBr+H20. 
C19H22N202,2HBr 
+2HoO... 
H22N202,HI  :  
H22N202,2HI+H20  
+2H20  
H22N202,HN03  +  ,2H20 
EL.N.O^HNOs+HaO . 
On 
Oi  9H22N20; 
C    H  ] 
2(C919H2N2202),H2S04+6H20. 
C19H22N202,H2S04+2H20 
C19H22N202,CH202  
>C19H22N202,C2H402+2H20 .. 
2(C19H22N202),C2H204+2H20. 
2(C19H22N202),C,H606+2H20  
100  parts 
of  water 
dissolve 
^8 
171 
0.82 
7-  99 
0.94 
6-67 
1-  06 
8-  20 
2-  08 
012 
018 
(at  100°) 
1-36 
0-91 
118 
5-88 
(at  100°) 
025 
017 
Specific  rotato^  power 
Concen- 
tration 
=  P 
V* 
0-0069 
0-0056 
0-0.109 
0-0119 
0-0019 
0-0156 
0-0080 
0-0150 
0-0113 
00128 
0-0103 
0-0095 
0-0048 
Of  the 
salt. 
-157'10 
-211-0 
-145-8 
-189-0 
-126-3 
-151-2 
138-4 
1794 
144-9 
-202-4 
163-8 
Of  the 
base. 
175-4° 
184-7 
-283-8 
192-7 
-287-7 
178-4 
-283-2 
-182  5 
-289-1 
-184-4 
-2899 
183-0 
case  of  cupreine  dihydrochloride,  the  specific  rotatory  power  was  found 
to  diminish  with  the  addition  of  free  hydrochloric  acid  to  the  solution. 
It  was  also  found  that  the  calculated  specific  rotatory  power  of  the 
base  is  much  greater  in  the  normal  than  in  the  basic  salts.  It  has 
nearly  constant  values  of  285"4°  and  185*4°  respectively.  The  salts, 
with  2  mols.  of  a  monobasic  acid,  are  also  more  soluble  than  those  with 
1  mol. 
The  table  summarizes  the  data  regarding  the  salts  of  cupreine ; 
many  of  these  salts  have  already  been  prepared  by  Hesse,  or  by  Paul 
and  Cownley. 
