70 
Homatropia  Hydrohr ornate. 
(Am.  Jour.  Pharm. 
\      Feb.,  1881. 
with  evolution  of  carbonic  anhydride^  but  without  being  blackened .. 
When  distilled  with  excess  of  calcium  hydrate  the  distillate  smells 
strongly  of  pyridine.  The  normal  barium  salt,  C^HgBaNO^,  forms  tufts 
of  needles,  which  are  sjDaringly  soluble.  The  normal  calcium  salt 
crystallizes  in  large  prisms,  and  is  more  easily  soluble  than  the  barium 
salt;  when  dried  in  air  it  retains  SjHgO.  The  normal  silver  salty 
C7H3Ag2N04,  is  anhydrous,  and  not  much  altered  by  exposure  to  light. 
The  acid  silver  salt,  C-.H4AgN04,  is  obtained  by  dissolving  the  acid  in 
boiling  water,  with  addition  of  a  few  drops  of  nitric  acid,  and  adding 
silver  nitrate.  It  is  crystalline  and  anhydrous.  The  normal  copper 
salt,  C7H3CUNO4+4H2O,  forms  dark  blue  sparingly  soluble  crystals., 
It  loses  its  water  of  crystallization  at  180°. 
Cinchomeronic  acid  splits  up  on  heating  into  pyrocinchomeronic  acid 
(^'Ber.,"  xiii,  61)  and  nicotinic  acid,  whilst  carbonic  anhydride  is 
evolved. 
The  action  of  permanganate  on  the  four  cinchona  alkaloids  seems  tO' 
be  as  follows :  In  the  first  stage,  the  molecules  containing  two  nitrogen 
atoms  are  split  into  two  groups,  containing  one  atom  of  nitrogen  in 
each.  In  the  second  stage,  the  nitrogen  of  one  of  these  groups  is  evolved 
as  ammonia,  while  from  the  other  several  bodies  containing  nitrogen  are 
obtained,  among  the  rest  tricarbojiyridinic  acid. 
The  authors  do  not  agree  with  Weidel  and  Herzig's  supposition  that 
cinchomeronic  acid  is  constituted  (according  to  Korner's  pyridin  and 
quinoliii  formula)  as  1.2.3,  the  nitrogen  having  the  place  1 ;  but 
they  assign  this  constitution  to  their  quinolic  acid  obtained  by  the  action 
of  permanganate  on  quinolin,  and  which  they  consider  to  be  the 
normal  oxidation  product  of  this  body. — Jour.  Chem,  Soc,  Dec.  1880,, 
from  Liehig^s  Annalen. 
Homatropia  Hy drobromate. — Dr.  Fronmuller  reports  in  "Allg. 
Medic.  Central  Zeitung"  a  number  of  experiments,  by  hypodermic 
and  internal  use,  made  for  the  pur^^ose  of  ascertaining  the  dose  produ- 
cing the  first  symptoms  of  intoxication,  which  appeared  on  taking  in  a 
day  12  pills  (three  times  4  pills),  each  containing  5  milligrams  (3^ 
grain)  of  the  salt.  The  symptoms  were  dryness  and  irritation  in  the 
throat,  congestion  of  the  head  and  light  vertigo.  The  pulse  was  rather 
variable,  in  some  cases  unchanged,  while  in  others  it  was  lessened  or 
more  frequent. 
