Am.  Jour.  Pharm. "( 
April,  1881.  J 
Researches  on  the  Cinchona  Alkaloids, 
163 
ether;  this  preci2)itate  is  apparently  crystalline  when  produced  at  an 
elevated  temperature.  Ammonia,  caustic  potassa  and  caustic  soda  dis- 
solve the  alkaloid  but  slightly;  it  possesses  an  alkaline  reaction  in 
alcoholic  solution  and  is  Isevogyrate,  dissolved  in  alcohol,  — 149'1°,  and 
in  water  with  3HC1,  —245-7°.  Its  melting  point  is  at  160°C  (uncorr.). 
Its  acid  sulphuric  aeid  solution  shows  no  fluorescence,  with  chlorine 
and  ammonia,  however,  it  gives  in  alcoholic  solution  a  yellow  coloration. 
With  hydrochloric  acid  it  forms  an  acid  salt,  Ci9H23ClN202,2HCl  + 
3II2O,  crystallizing  in  colorless  needles,  which  are  very  difficultly  soluble 
in  moderately  dilute  hydrochloric  acid,  but  dissolve  very  readily  in 
water  and  alcohol. 
Zorn  analyzed  the  compound  which  had  been  dried  in  vacuo  over 
potassium  hydrate  and  it  contained  only  IHgO. 
The  chloroplatinate  is  a  dark  yellow,  flocculent  precipitate,  at  first 
.amorphous,  but  afterwards  becoming  crystalline. 
HydrocMorapoqidnidia,  C\9H23C1N202. — If  the  contents  of  the 
tubes^  be  mixed  with  some  water,  the  dichlorhydrate  of  hydrochlor- 
apoquinidia  separates  in  crystals,  which  can  be  purified  either  by 
Tecrystallizing  from  dilute  hydrochloric  acid  or  by  treatment  with  hot 
alcohol,  in  which  case  it  remains  undissolved. 
The  aqueous  solution  of  the  salt  is  then  precipitated  w^th  a  slight 
excess  of  ammonia,  and  the  alkaloid,  which  is  obtained  in  delicate  white 
flakes,  washed  witli  cold  water  and  dried  by  exposure  to  the  air,  when 
it  forms  almost  colorless  lumps,  yielding  a  white  powder.  The  hydrate 
contains  2H2O. 
The  alkaloid  dissolves  readily  in  ether  and  alcohol  and  slightly  in 
boiling  water;  the  latter  solution  becomes  turbid  upon  cooling,  appar- 
ently separating  crystals.  The  alcoholic  solution  is  colored  yellow  (not 
green  as  stated  by  Zorn)  upon  the  addition  of  chlorine  and  ammonia. 
The  alkaloid  melts  at  164°  (uncorr.)  and  assumes  thereby  a  brown 
color.  Its  solution  in  alcohol  rotates  +203*7°,  and  in  water  with 
3HCl  +  258'4°.  Its  solution  in  dilute  sulphuric  acid  shows  no 
fluorescence,  and  is  precipitated  by  ammonia  or  caustic  soda  in  white 
flakes,  the  liquid  at  the  same  time  assuming  a  yellow  color.  The 
^  Among  eight  tubes  which  had  been  charged  with  crystallized  quinidia 
and  highly  concentrated  hydrochloric  acid,  one  was  found  in  which  glit- 
tering crystals  had  separated,  insoluble  in  l)oiliiig  water  and  in  dilute  and 
concentrated  hydrochloric  acid.  They  were  filtered  off  before  precipitating 
with  water,  but  in  consequence  of  the  small  amount  obtained  have  not  yet 
been  examined. 
