'^'"b^'riss'r""  }  Strength  of  Spiritus  jEtheris  Nitrosi.  605> 
with  trituration,  and  afterwards  48  cc.  of  distilled  water.  The  mix- 
ture was  heated  on  a  water-bath  for  one  hour,  transferred  to  a  wet- 
ted filter,  the  sediment  well  washed  with  warm  water,  and  the  fil- 
trate evaporated  to  50  cc.  While  still  warm,  2  cc.  of  ether,  6  drops 
of  benzol  and  2' 2  grams  of  ammonium  chloride  were  added,  and  after 
24  hours  the  crystals  were  transferred  to  a  dried  filter,  washed  with. 
16  cc.  of  water,  dried  at  50°C.  and  weighed. 
Staples^  Process. — 50  grams  of  the  tincture  were  evaporated  on  a 
water-bath  to  one-half  the  bulk,  set  aside  for  24  hours  and  a  vis- 
cid sediment  separated  by  decantation  and  filtration ;  an  equal  bulk 
of  alcohol  was  added  and  afterwards  a  mixture  of  2*6  cc.  water  of 
ammonia,  sp.  gr.  '960,  with  3'4  cc.  alcohol.  After  four  days  the 
crystals  were  collected  as  before ;  they  were  much  whiter  than  those-, 
obtained  by  the  first  process. 
The  results  were  as  follows : 
From  Fifty  Grams.  From  One  Fluidounce. 
No. 
Sp.  Gr. 
Hager's 
Process. 
staples'  Process. 
Ilager's  Process. 
staples'  Process, 
Grams. 
Grains. 
Grams. 
Grains. 
Grams. 
Grains. 
Grams. 
Grains. 
1 
•954 
•53 
8-17 
•52 
8-02 
•30 
4-60 
•29 
4.52 
2 
•962 
•38 
5-86 
•32 
4-94 
•22 
333 
•18 
2-81 
3 
•954 
•42 
6-48 
•40 
6-17 
•24 
3.65 
•23 
3^48 
4 
•967 
•36 
5-56 
•32 
4-94 
•21 
3-17 
•19 
2-82 
5 
•956 
•25 
3-86 
•22 
3^40 
•14 
2-18 
•12 
1-92 
The  tincture,  prepared  according  to  the  United  States  Pharmaco- 
poeia, with  opium  containing  10  per  cent,  of  morphia,  contains  in 
each  fluidounce  3*75  grains  of  morphia. 
THE  ETHERIAL  STEENGTH  of  SPIRITUS  ^THEEIS 
NITROSI. 
By  Henry  L.  Warne,  Ph.  G. 
From  an  Inaugural  Essay. 
The  method  adopted  depends  upon  the  conversion  of  ethyl  nitrite 
into  the  corresponding  potassium  salt  and  the  subsequent  oxidation  of 
this  compound  by  a  solution  of  permanganate  of  potassium  of  known 
strength.^  The  latter  was  made  by  dissolving  three  grams  of  the  crys- 
tallized salt  in  one  liter  of  distilled  water  and  standardizing  under  the 
usual  precautions  with  a  fresh  solution  of  pure  iron  (pianoforte  wire). 
The  mean  of  two  closely  agreeing  experiments  gave  1  cc.  of  the  solu- 
tion oxidizing  '004861336  gram  of  iron  from  the  ferrous  to  the  ferric 
1  See  "  Amer.  Jour.  Phar."  1880,  p.  603. 
