-Am.  Jour.  Pharm.  \ 
Dec,  1881.  J 
Alkaloids  from  Nux  Vomica. 
613 
1.  The  crystalline  portion  was  converted  into  hydriodide,  recrystal- 
lized  from  alcohol,  and  regenerated  as  before,  but  with  this  difference, 
that  the  final  precipitation  with  ammonia  of  a  large  part  of  it  was 
done  fractionally,  so  as  to  yield  the  alkaloid  in  three  fractions,  A — 1, 
A — 2,  A — 3,  a  small  portion  (1*5  per  cent.)  remaining  in  solution; 
this  part  was  only  examined  qualitatively.  It  exhibited  no  point  of 
difference  from  the  rest. 
On  combustion  the  three  fractions  gave  results  stated  under  III, 
IV,  V  and  VI. 
2.  The  portion  of  the  alkaloid  extracted  by  chloroform  from  the 
aqueous  mother-liquor  of  the  portion  which  crystallized,  after  purifi- 
cation by  recrystallizing  the  hydriodide  and  regenerating  in  the  man- 
ner described,  was  dried  at  105°  to  107°,  and  analyzed  (No.  VII). 
The  percentages  corresponding  to  these  various  analyses  stand  as 
follows : 
C.  H.         N.  O. 
I    .  .  .    69-52  6-62 
II 
III  .  .            .    69-70  6-71 
IV  .  .         69-54  6-60 
V  .            .            .    69-89  6-50 
VI  .            .          69-49  6-54 
VII  .            .            .    69-95  6-64 
7-2 
Mean         .  .         69-68         6-60         7*2  16-52 
The  accepted  formula  for  brucine,  0-2^2^2^^^  requires  C  70*0, 
H  6-64,  N  7-1,  O  16-26. 
Two  determinations  of  platinum  in  platinum  salt  gave  results  cor- 
responding in  each  case  to  16'22  per  cent,  of  Pt.  The  present  for- 
mula requires  16*43  per  cent,  of  Pt. 
Three  determinations  of  iodine  in  hydriodide  gave  respectively 
24-47  per  cent.,  24-25  per  cent.,  24*33  per  cent.  Mean,  24*38  per 
cent.    The  accepted  formula  requires  24*34  per  cent,  of  iodine. 
The  results  of  these  various  analyses  leave  no  doubt  that  the  for- 
mula €231125X204,  already  accepted,  is  correct,  and  hence  it  appears 
that  brucine  employed  by  previous  experimenters  prepared  by  the  old 
processes,  was  not  a  saponification  product  of  the  alkaloid  present  in 
the  seeds,  nor  mixed  with  any  such  substances,  but  that  the  alkaloid 
in  the  seeds  is  identical  with  that  which  they  obtained.  I  have 
found  in  experiments  described  further  on  tliat  brucine  is  without 
doubt  profoundly  affected  by  heating  with  acids,  alkalies,  or  even 
