646       Recent  Literature  Relating  to  Pharmacy.    { ^vimber^s^" 
TJierapist,  September  15,  1897),  relates  his  experience  with  cinnamic 
acid  in  the  treatment  of  tuberculosis.  He  states  that  the  theory 
upon  which  the  method  of  using  cinnamic  acid  is  based,  was  pro- 
pounded by  Landerer  in  1888.  The  important  points  to  be  noted 
in  the  treatment  are:  (1)  Induction  of  general  leucocytosis.  (2) 
Aseptic  inflammation  of  the  tuberculous  centre,  commencing  with  a 
circumvention  and  permeation  of  the  tubercles  with  leucocytes, 
subsequently  with  young  vessels  and  vascular  tissue.  To  bring 
about  these  conditions,  Landerer  used  an  intravenous  injection  of  an 
emulsion  of  cinnamic  acid;  but  Dr.  Heusser  prefers  to  use  gluteal 
injections  of  the  emulsion  on  account  of  the  danger  attending  the 
former  method  of  administration.  He  uses  a  minim  and  a  half 
of  a  5  per  cent,  emulsion  for  the  beginning  dose,  which  he 
increases  gradually  with  each  injection.  If  the  symptoms  are  favor- 
able, these  are  made  every  second  day.  The  maximum  dose  is 
15  grains  and  is  continued  until  the  end  of  the  treatment,  which  is 
continued  for  a  month  after  all  symptoms  disappear. 
In  summarizing  his  opinions  with  regard  to  his  experience  with 
this  treatment,  the  author  stated  that:  (1)  Cinnamic  acid  is  a  drug 
having  great  influence  on  tuberculosis.  (2)  The  gluteal  cinnamic  acid 
injections,  if  cautiously  made,  are  absolutely  innocuous.  (3)  The 
gluteal  cinnamic  acid  treatment  is  capable  of  curing  a  considerable 
number  of  cases  of  pulmonary  tuberculosis.  (4)  Cinnamic  acid  is 
not  a  specific  against  tuberculosis. 
Citric  acid  is  reported  as  manufactured  in  San  Diego,  Cal.,  a  factory  for  its- 
manufacture,  along  with  oil  of  lemon,  having  been  established  in  1896.  It 
takes  from  four  to  six  weeks  to  condense  the  juice  from  60  to  70  pounds 
of  lemons  into  1  pound  of  acid.  The  factory  employs  seven  hands,  has 
steam  works,  and  a  capacity  for  40,000  lemons  a  week  ;  only  culls  are  used. — 
Chem.  Trade  Jour.,  October  2,  1897. 
Cadmium  is  meeting  with  an  increasing  demand,  and  the  shortage  in  the 
supply  still  continues,  notwithstanding  a  little  more  is  being  made  in  Upper 
Silesia  (which  is,  practically,  the  only  district  where  cadmium  is  produced). 
The  Upper  Silesian  production  in  the  first  quarter  of  the  current  year  was 
3,326  kilos,  valued  at  11*844  marks  per  kilo,  against  3,256  kilos,  valued  at 
10*261  marks  per  kilo  in  the  last  quarter  of  1896  ;  and  2,436  kilos,  valued  at 
5*380  marks  per  kilo  in  the  first  quarter  of  1896.  At  present,  it  is  said  the  metal 
is  lacking  entirely,  and  urgent  demands  for  it  cannot  be  satisfied.  If  the  new 
demand  proves  to  be  permanent,  however,  there  will  be  no  difficulty  in  meet- 
ing it,  since  most  of  the  Upper  Silesian  ore  is  cadmium-bearing,  and  the  metal 
can  be  recovered  without  difficulty  as  a  by-product. — Eng.  and  Mining  Jour.t 
October^  1897. 
