Am,  Jour.  Pharm.) 
February ,  1902.  / 
Progress  in  Pharmacy, 
89 
reported,  and  even  French  physicians  admit  that  they  do  not  always 
obtain  favorable  results.  The  alleged  freedom  from  ill  effects  is  due 
(Apothkr.  Zeitg.,  1901)  to  the  fact  that  the  drug  is  largely  eliminated 
with  the  fecal  matter,  without  having  been  decomposed  or  changed 
in  any  way. 
Chloretone  is  another  of  the  new  drugs  that  has  not  come  up  to 
the  expectations  of  the  average  physician ;  not  being  soluble  in 
water,  it  has  not  always  met  with  success  as  a  local  anaesthetic. 
Hedonal  has  been  reported  on  from  various  quarters ;  several 
authors  object  to  the  peculiar  and  disagreeable  taste  of  the  drug. 
Secondary  effects  are  said  to  be  not  uncommon,  but  not  serious;, 
one  of  the  more  disagreeable  is  due  to  the  fact  that  the  substance 
is  also  a  diuretic.  This  action  is  at  times  so  pronounced  that  it 
interferes  with  continued  sleep. 
Hetol. — Sodium  cinnamate.  Kuhn  (Munch,  Med.  Wochschrf.,  1901) 
considers  that  the  improvement  in  cases  of  tuberculosis  treated  with. 
intravenous  injections  of  this  drug  was  so  slight  that  they  may 
easily  be  accounted  for  by  improvement  in  hygiene  and  surround, 
ings.  Gidion  (Deutsch.  Arch.  f.  Klin.  Med.,  1901)  comes  to  the  same 
conclusion,  and  even  reports  several  cases  that  have  lost  weight 
under  treatment. 
Honthi?i. — Frieser  (Therapist,  1901)  describes  this  compound  as 
a  combination  of  tannin  with  albumin  and  keratin.  He  has  used 
it  in  thirty-two  cases  with  favorable  results  and  believes  it  to  be 
half  as  powerful  again  as  tannalbin.  It  is  given  in  doses  of  from 
0-5  to  ro  three  or  four  times  a  day. 
Ichthyoform  is  a  combination  of  ichthyol  with  formaldehyde 
Average  dose  i-o  to  2-0,  used  in  diarrhoea  due  to  intestinal  tuber- 
culosis, also  used  with  good  effect  in  the  diarrhoea  of  typhoid 
fever.  It  is  said  to  combine  the  analgesic  and  astringent  action  of 
ichthyol  and  the  exceedingly  energetic  influence  of  formic  aldehyde. 
Igazol,  supposedly  a  mixture  containing  formaldehyde  and  iodo- 
form, has  been  reported  on  unfavorably  by  Wolff  (Deut.  Med, 
Wochschrf.,  1901). 
Purgatin,  the  diacetate  of  anthrapurpurin,  is  one  of  the  most 
interesting  possibilities  in  the  field  of  synthetic  chemistry.  It  is 
probably  the  first  compound  that  promises  to  be  a  more  or  less 
efficient  aperient  or  cathartic.  It  was  at  first  marketed  under  the 
name  purgatol,  and  is  an  orange-yellow  crystalline  powder,  insol- 
