AmAJpOrn;l902!^m■}      Deodorized  Opium  and  Tincture.  159 
taken  up  or  dissolved  by  the  solvent.  Dr.  Carson,  then  the  editor 
of  this  publication,  in  a  footnote,  calls  attention  to  the  fact  that  the 
prevailing  opinions  regarding  the  medical  properties  of  narcotine 
were  at  variance,  some  authorities  claiming  for  it  poisonous  proper- 
ties; others  asserting  that  it  had  hardly  any  toxic  properties,  if  not 
being  entirely  inert ;  while  still  others  claimed  for  it  stimulant  tonic 
characteristics. 
We  next  reach  the  contribution  of  Eugene  Dupuy,  of  New  York 
City,  in  the  American  Journal  of  Pharmacy  for  July,  1851, 
entitled,  "  On  a  Substitute  for  McMunn's  Elixir  of  Opium."  The 
process  advanced  consisted  in  the  use  of  cold  water  in  extracting 
the  opium,  and  in  all  essential  features  was  similar  to  the  formula 
of  Duhamel.  A  footnote  to  this  paper  by  the  editor,  Prof.  William 
Procter,  Jr.,  is  very  comprehensive,  and  in  summing  up  he  says : 
"In  glancing  over  the  long  list  of  the  constituents  of  opium  with 
the  view  of  singling  out  those  to  which  the  unpleasant  effect  of 
laudanum  may  be  attributed,  perhaps  none  are  more  open  to  sus- 
picion than  the  odorous  principle,  resin,  acid  extractive,  thebaine, 
and  perhaps  codeine  and  7iarcotine  to  some  extent,  although 
O'Shaughnessy  and  others  have  shown  that  it  is  extremely  doubtful 
that  the  latter  {narcotine)  possesses  any  disturbing  quality  of  the 
kind."  Further  on  he  says:  "  Landerer,  on  page  251  of  this 
number  of  the  Journal,  speaks  of  the  nauseating  and  other  un- 
pleasant effects  produced  by  the  exhalations  from  poppy  planta- 
tions during  the  collection  of  opium.  May  not  the  odorous  prin- 
ciple have  something  to  do  with  this  effect,  and  may  not  the  removal 
or  loss  of  this  in  the  so-called  denarcotized  laudanum  and  in  old  opium 
pills  be  at  least  partially  the  reason  of  their  diminished  tendency  to 
produce  nausea  and  headache  ?"  He  continues  by  saying  :  "  Pro- 
fessor Redwood  considers  the  'sedative  liquor  of  Battley'  to  be  an 
aqueous  solution  of  opium  evaporated  to  dryness  to  rid  it  of  the 
odorous  and  acid  resin,  re-dissolved  in  water,  and  a  small  portion 
of  spirit  added  to  give  it  permanence." 
Next  in  order  we  come  to  Dr.  E.  R.  Squibb's  contribution  which 
was  published  in  the  American  Journal  of  Pharmacy  for  March, 
i860.  It  is  entitled,  "  Opium  as  a  Therapeutic  Agent."  In  this 
paper  the  doctor  calls  attention  to  the  inefficiency  of  morphine 
and  its  salts  fully  to  represent  the  medical  properties  of  opium,  and 
gives  a  formula  for  a  liquid  preparation  of  the  drug  which  should 
