296 
Progress  of  Pharmacy. 
Am.  Jour.  Pharm. 
June.  1902. 
as  a  local  antiseptic  or  antiseptic  mouth-wash  in  solutions  of  1 
part  of  the  substance  to  200  or  500  of  water.    {Pharm.  Centralh., 
1902.) 
Sodium  bisulphate — NaHS04H20 — is  said  to  be  useful  in  modify- 
ing water  infected  with  typhoid  bacilli,  so  that  it  may  be  drank 
without  fear  of  infection.  When  used  in  the  form  of  compressed 
tablets  containing  0-30  of  the  bisulphate,  one  is  dissolved  in  a  glass 
of  water,  and,  in  addition  to  making  the  water  harmless,  it  will 
impart  an  agreeable  saline  and  slightly  acid  taste,  that  contributes 
materially  toward  quenching  the  thirst.    {Pharm.  Centralh.,  1902.) 
Sodium  persulphate  and  ammonium  persulphate  have  been  sug- 
gested and  used  as  remedies  to  stimulate  or  improve  the  appetite, 
given  in  doses  of  o-io  half  an  hour  before  eating.  In  Germany  a 
solution  is  being  sold  under  the  trade  name  Persodine  ;  this  [Pharm. 
Centralhalle,  1902)  is  said  to  be  made  as  follows : 
2.  Sodium  persulphate. 
300.  Distilled  water.  Mix. 
Give  a  tablespoonful  half  an  hour  before  eating. 
Quinine  for  hypodermic  use. —  A  solution  ol  this  alkaloid  may  be 
prepared  according  to  Gaglio  (Chem.  Zeit.,  1902)  by  dissolving  3 
grammes  of  quinine  hydrochlorate  or  hydrobromate  and  1*5  grammes 
of  urethan  in  3  grammes  of  distilled  water.  This  combination  con- 
tains about  two  molecules  of  urethan  to  each  molecule  of  the 
quinine  salt.  This  of  course  recalls  the  Fact  that  there  are  other 
chemicals  that  will  form  molecular  combinations  with  quinine  salts 
and  in  this  way  facilitate  solution.  Urea  was  suggested  many  years 
ago,  and  with  the  reintroduction  of  this  remedy  into  active  use  the 
combination  with  quinine  will  probably  be  found  applicable  in  some 
cases.  Another  chemical  that  appears  to  combine  in  a  molecular 
way  with  some  of  the  quinine  salts  is  chloral  hydrate ;  if  we  take, 
for  instance,  3  grammes  each  of  quinine  hydrochlorate  and  chloral 
hydrate,  they  will  readily  dissolve  in  from  3  to  5  grammes  of  water, 
making  a  limpid  solution  miscible  with  water  to  any  degree. 
Thebaine  hydrochlorate  has  been  recommended  in  cases  of  neuras- 
thenia, given  in  doses  of  0-05  to  0-20.    (Pharm.  Zeit.) 
Among  the  novelties  in  the  administration  of  drugs  we  find  bromo- 
farina  and  bromo-pan  ;  the  first  is  said  to  be  flour  mixed  with  a  cer- 
tain amount  of  a  soluble  bromide  salt  and  intended  for  the  preparation 
of  the  bread  or  biscuit.    Bromo-pan  is  evidently  bread  in  the  form 
