502  American  Pharmaceutical  Association.     { Aroctober,%!m' 
The  number  of  ex.  of  acid  consumed  multiplied  by  0-15037,  and 
then  0-112  added,  will  give  the  number  ot  grammes  of  morphine  in 
100  c.c.  of  the  tincture. 
The  Alkaloids  of  Adlumia  Cirrhosa. 
By  J.  O.  Schlotterbeck  and  H.  C.  Watkins. 
This  is  a  continuation  of  the  work  commenced  two  years  ago 
upon  the  root  of  the  first  year's  plant.  At  that  time  only  100 
grammes  of  the  dry  material  was  available  and  only  one  alkaloid, 
protopine,  was  identified.  In  this  investigation,  20  pounds  of  the 
dry,  entire  plant  of  the  second  year's  growth  was  employed.  The 
authors  state  the  difficulties  met  with  in  obtaining  the  drug  and 
give  their  experience  in  the  cultivation  of  the  plant  for  the  benefit 
of  those  who  may  at  some  later  time  wish  to  take  up  the  work  upon 
this  subject. 
The  method  of  isolation  of  the  alkaloids  depends  upon  their 
liberation  from  combinations  in  the  plant  by  means  of  very  dilute 
ammonia  water,  drying  the  drug,  extracting  with  chloroform,  re- 
covering the  chloroform,  extracting  residue  with  warm,  diluted 
acetic  acid  y^-i  per  cent.,  concentrating,  precipitating  with 
ammonia,  shaking  out  with  ether  and  separating  and  purifying  by 
the  selection  of  proper  solvents. 
Five  distinct  alkaloids  were  isolated,  including  protopine  which 
was  previously  reported. 
(1)  Protopine,  M.P.  204-2050,  C20H19NO5. 
(2)  /9-homochelidonine,  M.P.  1590,  C21H23N05. 
(3)  Adlumine  (new),  M.P.  1880,  C39H41N012. 
(4)  Adlumidine  (new),  M.P.  2340,  QoH^NOg. 
(5)  (?)  M-p-  176-1770. 
These  alkaloids  were  found  to  be  in  combination  with  at  least  two 
acids,  viz.:  citric  and  tartaric. 
The  Color  Compound  of  Stvlophorum  Diphyllum  and 
Chelidonium  Majus. 
By  J.  O.  Schlotterbeck. 
Many  years  ago  Probst  made  a  chemical  examination  of  Cheli- 
donium majus  and  obtained  a  bitter  yellow  color  body  which  he 
named  chelidoxanthin.    To  this  body  he  attributed  much  of  the 
