Aro*ctobera902!m'}    American  Pharmaceutical  Association.  507 
At  12.27  p.m.    Comb  bluing,  wattles  red. 
At  12.55  p.m.    Comb  very  blue,  wattles  paler. 
At  1.45  p.m.    Comb  dark  blue  and  cold,  wattles  blue  and  cool. 
At  4.15  p.m.    Comb  very  blue  and  cold,  wattles  very  blue  and 
cold. 
At  4  55  p.m.    Comb  very  blue,  wattles  still  blue. 
At  8.10  a.m.  next  day.    Tip  of  comb  still  blue,  wattles  pale. 
At  8.20  a.m.  day  after.    Comb  and  wattles  still  pale  and  cool. 
Experiment  IX. — Black  rooster,  5  pounds.  Comb  and  wattles 
red  and  warm;  at  12.35  P-M-  injected  filtrate  from  experiment  VIII, 
representing  all  of  the  fluid  extract  but  the  Cornutine  of  Keller. 
At  1  p.m.    Comb  tips  slightly  blue,  wattles  red. 
At  1. 1 5  p.m.  Comb  tips  still  pale  blue,  wattles  red  and  both 
warm. 
At  1.55  p.m.    One  tip  only  bluish,  wattles  red. 
At  3  p.m.    Both  wattles  and  comb  red  and  warm. 
These  experiments  (1)  show  that  the  fluid  extracts  of  ergot  used 
contained  active  principle  or  principles  that  cause  vaso-constriction ; 
(2)  that  the  product  of  the  assay  for  the  Cornutine  of  Keller  causes 
fully  as  much  constriction  of  the  arterioles,  and  is  hence  at  least 
part,  if  not  all,  of  the  efficient  part  of  ergot  that  causes  vaso-con- 
striction ;  (3)  that  what  is  left  of  the  fluid  extract  of  ergot  does  not 
contain  much,  if  any,  of  those  active  principles  of  ergot  which  pro- 
duce vaso-constriction  and  which  are  generally  considered  to  repre- 
sent the  efficiency  of  ergot ,  and  finally,  (4)  that  the  assay  of  fluid 
extract  ergot  lor  Keller's  Cornutine  is  a  correct  means  of  standard- 
izing this  drug  for  its  vaso-constriction  virtues  or  what  is  generally 
considered  to  be  its  therapeutic  efficiency. 
Contributions  to  the  Pharmacology  of  Narcotine. 
From  the  Research  Laboratories  of  Sharp  &  Dohme.    By  A.  C. 
Crawford,  M.D.,  and  A.  R.  L.  Dohme,  Ph.D. 
The  opinions  as  to  the  physiological  activity  of  narcotine  have 
varied  widely.  It  was  considered  by  its  discoverer,  Derosne,  to  be 
the  active  principle  of  opium,  whence  its  name,  but  recently  Palmer 
has  suggested  the  name  anarcotine,  from  its  lack  of  narcotic  proper- 
ties. The  reports  of  the  earlier  experimental  work  vary  widely,  no 
doubt  owing  to  imperfect  methods  of  isolation.     Von  Schroeder 
