510  American  Pharmaceutical  Association.     {A  October,1  im'' " 
to  300  milligrammes  merely  induces  slight  drowsiness,  with  accel- 
eration of  the  respiration,  while  larger  doses,  0-5  gramme,  produce 
slightly  more  marked  dullness  and  disinclination  to  move,  in  one 
case  some  stiffening  of  the  limbs  and  marked  salivation ;  at  times 
tremors  and  restlessness  are  seen;  but  in  every  case,  with  one  excep- 
tion, the  dogs  would  come  to  you  on  being  called.  Unlike  mor- 
phine, it  induces  no  vomiting  or  purgation  in  dogs. 
A  cat  (8  pounds)  and  a  rooster  (5  pounds)  in  our  hands  were 
apparently  unaffected  by  64  milligrammes  hypodermically. 
Rabbits  were  used  by  v.  Schroeder.  He  iound  that  0-5  gramme 
per  ounce  caused,  in  fifteen  to  twenty  minutes,  slight  trembling  with 
some  restlessness  ;  then  followed,  for  about  one-half  to  one  hour,  a 
stage  of  increased  reflex  excitability,  then  a  return  to  normal.  The 
narcotic  action  was  very  slight  and  uncertain  in  appearing.  After 
the  administration  of  1-2  grammes,  the  stage  of  excitement  is  suc- 
ceeded by  one  of  depression,  in  which  paralytic  symptoms  appear, 
and  death  in  about  forty  hours. 
In  frogs,  the  hypodermic  injection  of  0-05-0  07  gramme  produces 
a  somewhat  similar  picture ;  first,  a  stage  of  diminished  reflex 
excitability,  followed  by  one  of  increased  reflex  excitability,  and 
later  by  paralysis  (v.  Schroeder).  This  paralysis  is  mainly  central 
in  origin,  although  the  excitability  of  the  motor  nerves  is  dimin- 
ished. Pigeons  which  are  immune  to  morphine  die  with  convul- 
sions from  0-15  gramme  narcotine  (Liebreich,  "  Encyc.  d.  Ther.," 
Vol.  3,  p.  204)  so  that  in  animals,  any  narcotic  effect  is  very  slight 
and  often  uncertain. 
The  injection  of  narcotine  powder  under  the  skin  in  frogs  is  not 
followed  by  symptoms  of  narcotine  poisoning,  as  it  is  practically 
unabsorbed  in  this  condition  (V.  Schroeder).  Its  salts  are  very 
unstable,  so  that  it  should  be  used  in  weak  hydrochloric  acid  solu- 
tion. We  used  for  most  of  our  work,  solution  made  by  dissolving 
narcotine  in  HC1  N/20  and  controlled  the  experiment  with  HQ 
N /40,  calculating  that  the  difference  in  acidity  of  these  solutions 
would  be  neutralized  by  the  affinity  of  the  narcotine.  On  this 
solution,  moulds  grow  if  left  long. 
Numerous  experiments  upon  cats,  dogs,  rabbits  and  frogs,  as  well 
as  upon  adult  men  (full  details  of  which  will  be  found  in  the 
Proc.  A.Ph.A.,  1902)  have  indicated  that  the  following  conclusions 
are  justified : 
