so 
MISCELLANY. 
to fermentation, will yield still a very narcotic preparation. He found 
in the residue remaining in the preparation of the aqueous extract of 
opium, and of the acetate and muriate of morphia, brown extractive mat- 
ter , narcotine. fatty oil } resin^ caoutchouc, bassorine, with a gum- like sub- 
stance, sulphate of lime, $rc., with vegetable fibre. One part of this residue 
of opium, which is insoluble in cold water, was mixed with 175 parts of 
sugar and 40 parts of yeast, and exposed to a temperature of 77° Fahr. 
When fermentation had ceased, and the fluid had become clear, it was 
filtered and evaporated in a water-bath to dryness. The extract was 
again dissolved in water, and subjected with sugar and yeast again to 
fermentation, then re-filtered and evaporated. This fermented extract of 
opium is of a brown colour, and has a peculiar aromatic odour and bitter 
taste, producing a sensation of warmth on the palate. Two centigram- 
mes of this extract produced narcotism with head-ache in a strong man, 
and in a second experiment vomiting ensued. A dog of moderate size 
was killed by one gramme = 16 grains. This subject is worthy of 
further examination. — lbid } fro?n Rep sr. far die Phvrmacie. 
