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REMARKS ON FLUID EXTRACTS OF CINCHONA. 
REMARKS ON FLUID EXTRACTS OF CINCHONA. 
By the Editor. 
Whatever may be said in favor of the particular medicinal quali- 
ties of Quinia and its salts, and whether or not it really embodies 
all the curative joower of the cinchona barks, it remains to be 
true, that in many cases, a large number of physicians appeal to 
bark in substance, or in some galenical form, representing its solu- 
ble matter. The tinctures, the decoction, and infusion, and the 
several solid extracts, are called into service, but the former are 
too dilute and inefficient in ordinary doses, while the latter require 
to be administered in pilular form, which is not always desirable. 
It has therefore, been a desideratum to possess a preparation, hav- 
ing the conveniences peculiar to the fluid state, with such concen- 
tration as to render the bulk of the dose but moderate. 
Mr. Donovan of Dublin, some years since, proposed a prepara- 
tion (See Vol. xvii., p. 49, Am. Jour. Pharm.) which he called 
Syrup of Bark, but which required too much trouble and nicety of 
manipulation, to be generally adopted. He first exhausted eight 
ounces of calisaya with alcohol and water, evaporated the tincture 
and decoction separately, each to eight fluid ounces, mixed these, then 
added 315.31 grs. of dinoxalate of quinia, boiled a few minutes, 
and lastly dissolved in the liquid, 21 ounces of sugar, and four 
ounces of gum arabic, so that the whole should measure when 
complete, 32 fluid ounces. 
Since then, Mr. Isaac C. Jones, a graduate of the Philadelphia 
College of Pharmacy class '49 — '50, in his Inaugural Essay, 
proposed " a fluid extract of cinchona," made by exhausting eight 
ounces of yellow bark with water acidulated with muriatic acid, 
by the process of displacement, observing, to limit the quantity of 
muriatic acid to four fluid drachms, which is mixed with as much 
water as is necessary to exhaust the bark, viz., about four 
pints. The acidulated infusion is then evaporated to nine fluid 
ounces, and while yet hot, fourteen ounces of white sugar is dis- 
solved in it. so that when finished, the whole shall measure a pint. 
Each fluid drachm or teaspoonful of the syrupy solution, represents 
half a drachm of bark or about one grain of quinia. This pre 
paration is reddish brown and transparent when hot, but by cool- 
