356 
ON IODINE WITH QUININE AND MORPHINE. 
ON THE COMPOUNDS OF IODINE WITH QUININE AND 
MORPHINE. 
By F. L. Winckler. 
Equivalents of iodide of potassium and sulphate of quinine dis- 
solved in boiling water furnish regular crystals of sulphate of qui- 
nine free from iodine; and similar results are obtained when other 
salts of quinine with oxyacids are employed instead of the sulphate. 
Very different results are obtained with the hydraeids. Equiva- 
lents of muriate of quinine and iodide of potassium deposit a small 
quantity of a turpentine-like precipitate of iodide of quinine. 
Further experiment showed that, to decompose the muriate of qui- 
nine, 4 equivs. of iodide of potassium are requisite, and there is 
then produced a compound of — 
Iodide of Quinine, Ch 2 I. — This compound has, when dry, the 
properties of a resin ; after cooling, it is very easily reduced to 
powder, without becoming electric on friction, like pure quinine ; 
and it furnishes a perfectly white inodorous powder, of an ex- 
tremely bitter taste, which does not alter in the air. The com- 
pound is more soluble in water than the sulphate of quinine, and 
almost in every proportion in alcohol and in ether ; all the solu- 
tions are perfectly clear and colorless, and leave on evaporation 
the iodide of quinine in the form of a transparent resin. The salt 
is instantly decomposed, with elimination of iodine, by concen- 
trated sulphuric and nitric acids, and by chlorine; when burnt 
upon platinum foil, it left not a trace of potash ; the cinder is diffi- 
cult to burn. It furnished on analysis — 
Quinine, . . . 71-58 2 = 4111-024 72-166 
Iodine, .... 28-42 1 1585-570 27-834 
+■ / 'tiMst 
Iodide of Morphine, Mol, is obtained by dissolving 120 equivs. 
of dry acetate of morphine in 8 times the weight of cold distilled 
water, adding if necessary a few drops of pure acetic acid, and 
mixing the. filtered solution with a solution of 60 equivs. of iodide 
of potassium. After some time the salt crystallizes out in very 
slender crystals, which, however, are obtained of much larger size 
when the mixture is heated on the water-bath, and is allowed to 
cool slowly. In this manner it is obtained in transparent, shining, 
