Am.  Jour.  Pharm.  "1 
March,  1904.  J 
Progress  in  Pharmacy. 
135 
used  as  a  mydriatic  in  place  of  atropine.  In  action  it  is  said  to  be 
intermediate  between  homatropin  and  atropine.  (Phar.  Post,  1903, 
page  780.) 
Exodin. — This  is  the  trade  name  for  a  new  aperient  that  is  being 
marketed  in  Germany.  It  is  said  to  be  an  Oxy-anthra  quinone  de- 
rivative. It  is  a  yellow  powder,  insoluble  in  water  and  only  slightly 
soluble  in  alcohol.  The  adult  dose  of  exodin  is  from  1*00  to  1-50 
gm.    (Apothek.  Zeit.,  1904,  page  16.) 
Iboga. — A  Congo  plant  bearing  this  name  has  been  examined  by 
Landrin  and  Dybowsky.  Iboga  is  said  to  possess  properties  similar 
to  both  coca  and  kola.  Its  physiological  properties  are  due  to  an 
alkaloid,  named  by  the  investigators,  ibogaine.  Ibogaine  in  a  pure 
state  is  insoluble  in  water,  but  soluble  in  alcohol,  ether,  chloroform 
and  benzene.  Ibogaine  causes  local  anaesthesia  like  cocaine,  while 
in  its  action  on  the  medulla  oblongata  it  resembles  kola.  (Phar. 
Jour.,  1904,  page  107,  from  Schweiz.  Woc/t.) 
Iodterpin. — If  equal  parts  of  iodine  and  terpin  hydrate  are  finely 
powdered,  mixed,  and  then  gently  heated  on  a  water  bath,  they 
readily  unite  to  form  a  new  compound,  called  by  Mas  and  Grindel 
iodterpin.  Iodterpin  is  a  thick  viscid  liquid,  having  a  specific 
gravity  of  1-19  at  150  C.,and  boiling  between  165  and  1 75 0  C.  It  is 
readily  soluble  in  ether,  chloroform,  benzine  and  benzol,  and  has  a 
characteristic  odor,  somewhat  resembling  terpin  hydrate. 
Iodterpin  may  be  used  in  place  of  iodine,  and  has  also  been  sug- 
gested as  a  substitute  for  iodoform.   (Apothek.  Zeit.,  1904,  page  14.) 
Musk,  Artificial. — The  price  of  this  in  Germany  has  dropped 
from  1900  marks  to  125  marks  a  kilo.  This  decline  is  due  to  the 
fact  that  the  German  patents  have  expired.  The  Pharmaceutische 
Centralhalle,  in  commenting  on  this  marked  difference  in  price, 
expresses  the  hope  that  the  now  comparatively  low  price  will  not 
be  sufficient  inducement  for  the  too  liberal  use  of  this  particular 
perfume. 
Artificial  musk  should  not  be  confounded  with  the  natural  pro- 
duct, as,  despite  the  somewhat  striking  musk-like  odor,  it  is  quite 
different  in  composition  and  in  its  physiological  action.  Chemically, 
it  is  said  to  be  a  trinitrobutyl  derivative  of  toluol,  xylene  or  an  allied 
substance.  One  of  the  commercial  brands  that  is  said  to  have  an 
especially  fine  odor,  closely  resembling  that  of  musk,  is  said  to  be 
trinitro-iso-butyl-xylene. 
