216  Research  in  Manufacturing  Pharmacy.    { AmMayr'i904arm* 
the  air  in  the  sick-room  by  fumigating  powders  and  fumigating  essences  ;  on 
the  contrary,  we  will  make  it  clear  to  the  rising  generation,  with  our  utmost 
energy,  that  constant  renewal  of  air  is  the  best  odor-corrigent  of  the  sick-room. 
In  the  same  manner,  patients  who  suffer  from  bad-smelling  breath  should  not 
go  to  perfumery  shops,  but  to  the  dentist,  or  the  specialist  for  the  nose  or  the 
lungs.  Even  for  healthy  persons,  perfumes  are  only  admissible  in  homceo- 
pathically  minute  doses." 
The  reports  of  Schimmel  &  Co.  are  invaluable  and  have  contrib- 
uted much  to  a  healthful  development  of  the  essential  oil  industry, 
both  from  technical  and  medical  points  of  view. 
The  annual  reports  of  Merck  &  Co.,  on  "  The  Advancements  of 
Pharmaceutical  Chemistry  and  Therapeutics,"  have  also  been  im- 
portant contributions  to  pharmaceutical  and  medical  literature.  The 
present  report,  issued  last  July,  is  an  epitome  of  the  researches  for 
1902,  but  contains  much  information  that  even  yet  has  not  become 
thoroughly  disseminated  among  the  professions.  The  papers  by 
Prof.  R.  Kobert  on  "  Ipecacuanha  and  its  Active  Principles  "  are 
referred  to,  and  it  is  interesting  that  both  he  and  Carl  Lowin,  a 
student  of  Kobert,  confirm  the  investigations  of  Paul,  Cownley  and 
Wild  (see  this  Journal,  February  and  March,  1901),  that  emetine 
and  cephaeline  act  in  a  distinctive  manner,  emetine  giving  rise 
mainly  to  expectoration,  whilst  cephaeline  induces  prompt  and  facile 
vomiting. 
R.  B.  Wild  has  recommended  the  use  of  either  alkaloid  in  the  place  of  the 
galenic  ipecacuanha  preparations,  since  the  latter  contain  a  variable  propor- 
tion of  alkaloid,  according  to  their  origin  (?'.  whether  Rio  or  Carthagena  is 
used)  ;  whereas  the  alkaloids  possess  a  precise  therapeutic  value.  The  hydro- 
chlorate  and  hydrobromate  of  emetine  are  available  for  use  as  expectorants, 
depressing  media  or  emetics.  The  author  employs  a  very  permanent  solution 
of  o-o6  gramme  of  the  hydrobromate  in  30  c.c.  of  20  per  cent,  alcohol  and  pre- 
scribes of  this  5-20  drops  to  induce  expectoration  and  depression,  whilst  2  •0-5*0 
c.c.  serves  as  an  emetic  dose.  As  a  substitute  for  Dover's  powder,  Wild  em- 
ploys a  solution  containing  1  per  cent,  morphine  and  3^  per  cent,  hydro- 
chlorate  of  emetine.  Hydrochlorate  of  cephaeline  is  less  active  in  affections  of 
the  air-passages  than  the  emetine  salts.  Its  emetic  properties  are  so  intense  as 
to  render  it  difficult  to  properly  adjust  the  correct  dosing. 
The  "  Ephemeris  of  Materia  Medica,  Pharmacy,  Therapeutics  and 
Collateral  Information,"  by  Dr.  E.  H.  Squibb,  contains  brief  com- 
ments on  the  advances  of  the  year  ending  July  1,  1903.  Like  the 
preceding  firms'  publications,  "  Ephemeris  "  is  sent  to  all  those  who 
are  supposed  to  be  interested  in  its  contents.  The  first  paragraph 
in  this  monograph  is  well  worth  publishing  nearly  entire,  as  lor  some 
