126 
ON  IODINE  WITH  QUININE  AND  MORPHINE. 
creased  when  the  ink  is  required  to  be  more  stiff,  and  decreased 
when  it  is  required  to  be  more  fluid.  Pigments,  or  coloring 
matters  of  any  kind,  are  to  be  added,  as  in  other  cases. — London 
Pharm.  Jo  urn. 
THE  COMPOUNDS  OF  IODINE  WITH  QUININE  AND  MORPHINE. 
Br  F.  W.  Winckler. 
Iodide  of  Quinine. — When  iodide  of  potassium  and  sulphate  of 
quinine  are  dissolved  in  boiling  water,  in  equivalent  proportions, 
regular  crystals  (free  from  iodine)  of  sulphate  of  quinine  are  formed. 
A  similar  result  is  obtained  when,  instead  of  sulphate  of  quinine 
any  other  salt  of  quinine  formed  with  an  oxy-acid  is  used.  The 
hydro-acids  give  a  contrary  result.    A  mixture  of  hydrochlorate  of 
quinine  and  iodide  of  potassium,  in  equivalent  proportions,  precipi- 
tates a  small  quantity  of  iodide  of  quinine  in  a  resinous  state. 
For  the  complete  decomposition  of  the  hydrochlorate  of  quinine, 
Winckler  has  found  that  four  equivalents  of  iodide  of  potassium 
are  necessary.    The  compound  then  produced  consists  of  two 
equivalents  of  quinine,  with  one  equivalent  of  iodine,  or  126  parts 
of  iodine  and  328  parts  of  quinine.    This  combination  has,  when 
dried,  the  properties  of  a  resin.      W7hen  cold,  after  being  tho- 
roughly dried,  it  is  easily  powdered  without  being  electric,  as  the 
pure  quinine  is  when,  rubbed.    It  is  white,  without  smell,  perma- 
nent in  the  air,  and  possesses  a  very  bitter  taste.    It  dissolves  con- 
siderably in  water,  almost  in  any  quantity  of  spirit,  and  also  in 
ether.    All  these  solutions  are  clear,  colorless,  and  leave  behind, 
when  evaporated,  the  iodide  of  quinine  in  the  form  of  a  transpa- 
rent resin.    By  chlorine,  concentrated  sulphuric  and  nitric  acids, 
this  salt  is  immediately  decomposed,  wTith  the  separation  of  its 
iodine.    Its  combustion  on  platina  foil  is  with  difficulty  effected, 
and  the  residuum,  after  combustion,  contains  no  trace  of  potash. 
The  analysis  of  this  salt  gave — 
Found.  Calculated. 
Quinine,       -       -     71,58       -      -  72,166 
Iodine,         -       -     28,42       -      -  27,834 
100,00  100,000 
Iodide  of  Morphine. — This  salt  consists  of  one  equivalent  of 
morphine  and  one  of  iodine.      It  is  to  be  obtained  by  dissolving 
