CHEMICAL  COMPOSITION  OF  QUINIDINE. 
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of  kinoyl  and  of  oil  of  bitter  almonds,  and  leaves  behind  a  volumi- 
nous, easily  combustible  charcoal.  The  taste  of  quinidine  is  not 
so  intensely  bitter  as  that  of  quinine. 
In  order  to  determine  its  solubility,  quinidine  was  rubbed  down 
with  water  of  17°  C,  and  shaken.  36.1  grammes  of  the  solution 
left,  after  evaporation,  0.014  grams,  of  quinidine,  dried  at  100°; 
one  part  of  quinidine,  therefore  was  soluble  in  2580  parts  of  water 
at  17°. 
42.7  grms.  of  pure  quinidine  dissolved  in  water  at  100°,  and  treat- 
ed as  before,  left  0.023  grms.  of  quinidine  =  1  part  to  1858  parts 
of  water  at  100°  C. 
The  solubility  in  ether  was  determined  by  shaking  finely  pow- 
dered pure  quinidine  with  ether  of  0.728  spec.  grav.  at  17°  ;  19.4 
grms.  of  this  solution,  by  evaporation  yielded  0.137  grms.  of 
quinidine  dried  at  100°,  or  100  parts  of  the  solution  contain  0.70 
of  quinidine.  According  to  Winkler,  100  parts  of  ether  dissolve 
0.592  parts  of  quinidine.  One  part  of  quinidine  dissolves  in  12 
parts  of  alcohol  of  0.835  spec.  grav.  at  17°. 
Analysis  of  Quinidine. — 1.  Crude  quinidine  finely  powdered 
and  dried  at  100°  until  it  lost  nothing,  yielded  : 
i.  ii. 
Carbon,  .  .  77.34  .  .  .  77.02 
Hydrogen,     .        .       7.86        .        .        .  7.90 
2.  Pure  Quinidine,  obtained  by  being  four  or  five  times  re-crys- 
tallized from  alcohol,  finely  triturated  and  shaken  five  or  six  times 
with  ether,  till  chlorine  water  and  ammonia  produced  no  reaction 
of  quinine,  was  washed  with  water  and  dried  at  110°,  till  the 
weight  remained  constant.    The  results  were  : 
I.  II.  III.  IV.  V.  VI.  VII. 
Carbon,  .  .  76.88  76.82  76.79  76.40  76.55  76.49  — 
Hydrogen,  .  7.70  7.76  7.77  7.73  7.70  7.81  — 
Nitrogen,  —  9.99 
With  reference  to  the  analysis  of  the  salts  of  quinidine,  and 
the  determination  of  the  atomic  weight  of  the  base  from  the  pro- 
portion of  platinum  in  the  platinum  double  salt,  the  following  for- 
mula is  calculated  for  quinidine  : 
