164 
CHEMICAL  COMPOSITION  OF  QUINIDINE. 
Calculated. 
36  equiv.  Carbon,    ...  216  ...  76.59 
22     «     Hydrogen,  .  .  22  .  .  .  7.80 
2     «     Nitrogen,    .  .  28  .  .  .  9.93 
2     «     Oxygen,  ...  16  .  .  .  5.68 
1     «     Quinidine,  =  282  .  .  .  100.000 
If  quinidine  be  subjected  with  hydrate  of  potash  and  a  small 
quantity  of  water  to  distillation,  a  yellow  oleaginous  substance  is 
obtained,  which  reacts  as  an  alkali,  and  possesses  all  the  proper- 
ties of  quinoline.  Repeatedly  washed  with  distilled  water,  it  yielded 
a  beautifully  yellow  oily  liquid,  from  which  muriatic  acid  and  chlo- 
ride of  platinum  threw  down  an  orange-yellow  precipitate,  which,  af- 
ter having  been  perfectly  exhausted  by  cold  water,  was  dissolved 
in  hot  water.  When  cold,  the  platinum  salt  precipitated  from  the 
solution  in  the  form  of  small  orange-red  needles.  Dried  at  110°, 
0.695  grms.  of  the  platinum  salt  yielded,  after  being  burnt, 0.204 
grms.  of  platinum  =  29.35  per  cent.  If  the  formula  for  quino- 
line, C18H7N,  be  correct,  that  of  the  platinum  salt  of  quinidine 
would  be  CJ8  H7  N,  H  CI  PI.  Cl2,  and  the  salt  would  contain  29.47 
per  cent,  of  platinum. 
Finely  powdered  quinidine  dissolves  in  chlorine  water  without 
any  particular  phenomenon  ;  quinine  and  cinchonine  have  the  same 
relation  to  chlorine  water.  But  if  ammonia  be  added  to  these 
solutions,  the  cinchonine  falls  down  from  the  cinchonine  solution 
of  a  white  color,  the  quinine  solution  becomes  green  like  grass, 
and  the  quinidine  solution  remains  unaltered.  The  reaction  upon 
quinine  becomes  still  more  sensible  by  ether,  if  the  substance  to 
be  tested  for  quinine  be  first  finely  powdered,  then  shaken  with 
ether,  and  to  the  ether,  chlorine  water  and  ammonia  be  added, 
the  least  trace  of  quinine  may  be  detected  by  the  liquid  be- 
coming green.  By  this  test,  the  absence  or  presence  of  quinine 
could  very  easily  be  detected  in  the  preparation  of  the  quini- 
dine salts. 
Salts  of  Quinidine. — Most  of  these  salts  are  much  more  readily 
soluble  in  water  than  the  salts  of  quinine.  In  spirit  of  wine 
they  dissolve  very  easily,  in  ether  scarcely  at  all.  There  are 
acid  and  neutral  salts  of  quinidine,  of  which  there   are  but 
Average  of  the 
Experiments. 
.    .    .    .  76.66 
.    .    .    .  7.74 
.    .    .    .  9.99 
