166 
CHEMICAL  COMPOSITION  OF  QUINIDINE. 
The  clear,  very  acid,  and  strongly  opalizing  solution  was  eva- 
porated in  the  water-bath,  and  then  placed  under  the  air-pump, 
over  sulphuric  acid.  After  the  solution  had  arrived  at  the  consis- 
tency of  a  syrup,  and  had  assumed  an  intensely  brown  color,  a 
crystalline  mass  of  rather  thick  asbestos-like  needles  of  a  slight 
yellow  color  was  formed.  These  crystals,  after  being  removed 
from  the  mother-liquor,  were  washed  with  a  mixture  of  alcohol 
and  ether,  and  pressed  between  folds  of  filtering-paper,  which 
did  not  deprive  them  of  their  yellow  color.  The  proportion 
of  sulphuric  acid  in  the  salt  varied  considerably  several  times, 
which  arose  very  likely  from  lihe  presence  of  some  neutral/  sul- 
phate, and  for  this  reason  no  analysis  is  given. 
Neutral  Hydro  chlorate  of  Quinidine. — Pure  quinidine  was 
finely  powdered  and  mixed  with  water,  then  as  much  muriatic 
acid  added  by  drops  with  the  addition  of  heat,  till  the  whnle  of 
the  quinidine  was  dissolved,  and  the  solution  was  neutral  to  test- 
paper.  By  the  spontaneous  evaporation  of  the  solution  the  mu- 
riate of  quinidine  was  obtained  in  the  form  of  large  rhombic 
prisms  of  a  vitreous  lustre.  The  mother  liquor  yielded  no  crystals, 
even  after  having  been  evaporated  to  the  consistency  of  a  syrup 
and  left  standing  for  several  weeks  in  the  dry  air.  The  solubility 
was  determined  by  rubbing  down  the  crystallized  salt  with  water 
at  17°,  and  shaking,  till  the  latter  took  up  no  more  salt.  Of 
the  filtered  liquid  7.067  grms.  were  evaporated,  and  the  residue 
dried  at  100°,  weighed  0.252,=  1  part  of  the  salt,  therefore,  re- 
quired 27  parts  of  water.  Alcohol  dissolves  the  salt  very  easily, 
ether  scarcely  at  all.    Analysis  showed  in  100  parts  : 
Found.  Calculated. 
I.  II.  III.  IT. 
Carbon,  .    .    G4.57   .  .  G4.ll     .  .    —     ...     —     ...  64.19 
Hydrogen,  .     7.28    .  .    7.06     .  .    —    ...     —    ...  7.13 
Chlorine,    .      —     .  .     —      .  .  9.95    .  .  .  10.16  .  ,  .  10.25 
Corresponding  formula  : 
C36H22  No02,  2HC1,  2  HO. 
Acid  Hydrochiorate  of  Quinidine. — To  the  last  salt  as  much 
muriatic  acid  as  it  already  contained  was  added,  and  the  solution, 
left  to  evaporate  spontaneously,  yielded  beautiful,  large,  slightly 
