170 
CHEMICAL  COMPOSITION  OF  QUINIDINE. 
porcelain.  It  is  very  soluble,  and  smelt  strongly  of  butyric 
acid. 
Valerianate  of  Quinidine. — Aqueous  valerianic  acid  being 
saturated  with  an  alcoholic  solution  of  quinidine,  and  the  neutral 
solution  left  to  spontaneous  evaporation,  the  salt  soon  appeared 
in  the  shape  of  warty  crusts,  in  the  centre  of  which  was  a 
lighter  body  of  radiating  structure.  The  salt  smelt  strongly  of 
valerianic  acid.  The  solution  of  the  valerianate  of  quinidine  having 
been  evaporated  in  the  water-bath,  the  liquid  assumed  a  brown 
color,  emitting  a  penetrating  odor  of  valerianic  acid,  whilst  at 
the  same  time  oily  drops  were  evolved. 
Kinate  of  Quinidine  Pure  kinic  acid,  dissolved  in  water, 
was  saturated  whilst  heated  with  quinidine.  The  spontaneously 
evaporated  neutral  solution  yielded  a  white  milky  mass  of  small 
needles,  soluble  both  in  water  and  spirit  of  wine. 
Hippurate  of  Quinidine. — Pure  hippuric  acid,  dissolved  in 
spirit  of  wine,  was  saturated  with  quinidine  under  the  application 
of  heat.  The  hippurate  of  quinidine  crystallized  from  the  cold 
neutral  solution  in  long  silky  crystals,  which  had  the  appearance 
and  shape  of  fern  leaves.  It  dissolves  readily  in  water  and  in 
spirit  of  wine. 
In  comparing  the  following  formula  for  quinidine  with 
those  for  quinine  and  cinchonine,  the  following  relations  are 
established  : 
Quinidine  C3R  H22  N2  02. 
(  C38  IT22  N2  04  (Laurent.) 
Quinine,       £  C20  H12  N  02  (Liebig.) 
C  C38  H22  N2  02  (Laurent.) 
Cinchonine,  ^  C20  H12  N  0  (Liebig.) 
According  to  this,  quinidine  differs  from  cinchonine  by  a  lesser 
proportion  of  two  atoms  of  carbon,  whilst  the  equivalents  of 
the  other  elements  are  the  same.  An  homologous  relation  be- 
tween these  bases,  which  appears  so  very  probable,  cannot,  there- 
fore, be  established  Lon.  Pharm.  Jour.  Dec.  1852,  from  Ann. 
der  Chem.  u.  Pharm.,  Mai,  1852. 
