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OBSERVATIONS  ON  QUINTDINE. 
OBSERVATIONS  ON  QUINIDINE. 
By  Guisoxjrt  and  Bussy. 
From  the  experiments  of  these  two  chemists,  it  would  appear 
that  quinine  and  quinidine,  whatever  may  be  their  atomic  composi- 
tion, and  which  is  by  no  means  definitely  fixed,  are  two  distinct 
alkaloids,  and  possessed  of  different  chemical  and  physical  pro- 
perties. 
1st.  Quinine  separates  from  its  hydro-alcoholic  solution  in  the 
form  of  a  liquid  of  a  syrupy  appearance,  which  preserves  its  trans- 
parency on  drying  in  the  air.  However,  when  it  is  spread  in  a 
very  thin  layer  on  glass,  it  becomes  opaque,  taking  a  very  fine  and 
indeterminate  crystalline  structure.  In  the  first  state,  the  quinine 
appears  to  contain  3  equivalents  of  water,  or  14.29  per  cent. ;  in 
the  second  state,  it  contains  only  1  equivalent,  or  5.26  per  cent., 
the  equivalent  of  quinine  being  equal  to  C20  H12  N  02 
Quinidine  separates  from  its  hydro-alcoholic  solutions  in  the  form 
of  crystals,  which  belong,  according  to  the  authors,  to  the  system 
of  the  rectangular  or  rhomboidal  prism.  These  crystals  appear  to 
be  anhydrous,  for  they  do  not  sensibly  lose  weight  at  a  temperature 
of  212?  Fahr. 
2nd.  Quinine  is  soluble  in  every  proportion  in  cold  ether  and 
absolute  alcohol,  and  almost  in  every  proportion  in  alcohol  of  90°. 
Quinidine  requires  140  to  150  parts  of  cold  ether,  45  parts  of  abso- 
lute alcohol,  and  105  parts  of  alcohol  of  90°  to  dissolve  it;  it  is 
soluble  in  3.7  parts  of  boiling  absolute  alcohol. 
•  3rd.  Crystallized  sulphate  of  quinine  (bi-basic,  according  to 
Leibig  ;  neutral,  according  to  Regnault,)  is  soluble  in  57  parts  of 
cold  absolute  alcohol,  and  in  63  parts  of  alcohol  of  90°. 
The  corresponding  sulphate  of  quinidine  is  soluble  in  30  to  32 
parts  of  absolute  alcohol,  and  in  7  parts  of  alcohol  of  90°* 
4th.  Sulphate  of  quinine  is  soluble  in  265  parts  of  cold,  and  in 
24  parts  of  boiling  water. 
According  to  Mr.  Howard,  the  sulphate  of  quinidine  is  soluble 
in  73  parts  of  cold,  and  in  4.20  of  boiling  water.  According  to 
M.  Leers,  this  salt  is  soluble  only  in  130  parts  of  cold,  and  in  16 
parts  of  boiling  water.  (These  great  differences  may  be  accounted 
for  by  the  different  mode  of  operating.  Mr.  Howard,  for  example, 
judges  of  its  solubility  in  cold  water,  by  the  quantity  of  the  salt 
