402 
TINCTURA  CINCHONA  F ERRATA. 
filtrates  were  treated  with  another  portion  of  the  powdered  seeds, 
agitated  and  again  filtered:  In  these  filtrates  scarcely  a  vestige  of 
any  color  remained. 
TINCTURA  CINCHONA  FERRATA. 
By  Samuel  Simes. 
Huxham's  Tincture,  the  officinal  Compound  Tincture  of  Peru- 
vian Bark,  cannot  be  combined  with  any  of  the  ordinary  chaly- 
beates  without  an  offensive  decomposition,  seriously  affecting  its 
apparent,  if  not  its  real  characteristics.  These  reactions  were  ex- 
amined at  the  solicitation  of  Dr.  J.  F.  Meigs,  and  a  tincture  pre- 
pared, so  modified  that  it  is  no  longer  incompatible  with  the  salts 
of  iron.  Sixteen  grains  of  Ammonio  Citrate  of  Iron  are  dissolved 
in  each  fluid  ounce  of  this  modified  tincture,  together  constituting 
what  has  been  denominated,  for  distinction,  "  Ferrated  Tincture  of 
Bark." 
It  is  readily  prepared  by  digesting  in  the  Edinburgh  Compound 
Tincture  of  Cinchona,  sufficient  hydrated  sesquioxide  of  iron  to 
completely  eliminate  the  cincho-tannin,  whether  pure,  oxidized, 
or  combined.  One  ounce  of  hydrated  sesquioxide,  dried  at  a  tem- 
perature not  exceeding  130°  Fahr.,  usually  suffices  for  one  gallon 
of  the  tincture.  After  filtration,  the  tannate  and  excess  of  oxide 
should  be  washed  with  boiling  alcohol  to  remove  any  trace  of  al- 
kaloid which  may  have  been  in  combination  with  the  tannin  and 
precipitated  with  it.  This  alcoholic  solution  may  be  evaporated 
to  dryness,  the  product  dissolved  in  a  little  water  acidulated  with 
citric  acid,  and  added  to  the  filtrate  along  with  the  proper  quanti- 
ty of  iron  salt.  It  differs  little  in  appearance  from  the  ordinary 
Huxham's  tincture,  is  exceedingly  agreeable,  and  in  teaspoonful 
doses  has  become  a  very  energetic  invigorative,  admirably  adapted 
for  administration  in  those  cases  of  weak  and  languid  habits  of 
children  and  females,  where  the  body  is  in  a  pallid  or  flaccid  state, 
and  very  susceptible  of  fatigue  or  morbid  action. 
The  ferrated  tincture  is  not  solely  dependent  on  the  quinia 
and  iron  it  contains  for  its  value  as  a  curative  agent.  The  grate- 
ful, and  by  no  means  inefficient  adjuvants,  the  orange  peel  and 
snake  root,  and  the  other  proximate  principles  of  cinchona,  indepen- 
dant  of  quinia,  are  by  no  means  to  be  overlooked,  and  cannot  be 
