58  Fmdical  Notes  f  rom  Foreign  Journals.    { *'^"Veb 
with  1  to  3  grams  clierry  laurel  water  and  sweetened  with  ras})berry 
syrup;  should  nausea  be  observed,  a  tablespoonful  of  lemon-juice  or 
small  pieces  of  ice  may  be  given. 
The  absence  of  bitter  taste  renders  chinolijie  tartrate  of  peculiar 
importance  in  the  treatment  of  children.    A  good  formula  for  children 
of  4  to  8  years  is  the  following: 
H  Cliinolini  tartrat.,     .  .  .       TO  (gr.  xv) 
Aqu8e  destilL, 
Syr.  simplic,  .  .  aa  oO'O  (,:5xiiss) 
8.  To  be  taken  in  two  days  in  about  four  doses. 
A  mouth  luash  has  been  used  with  advantage  consisting  of  cliinoline 
tartrate  1*5,  distilled  water  140"0j  alcohol  20*0,  oil  of  peppermint  1 
drop ;  it  is  to  be  diluted  with  5  to  8  jiarts  of  water. 
The  price  of  chinoline  tartrate  is  about  one-fifth  that  of  quinine. — 
Phar.  Zeitung,  Oct.  19,  p.  630. 
Estimation  of  Alkaloids  as  Picrates. — Hager  recommends  the  gravi- 
metric estimation  of  alkaloids  by  a  solution  of  picric  acid,  saturated  at 
ordinary  temperatures.  The  alkaloids  are  preferably  employed  as  sul- 
phates in  moderately  acid  solution.  The  precipitation  should  be 
effected  below  15°C.  1  gram  of  nicotine  sulphate  requires  at  least 
300  cc.  of  the  picric  acid  solution,  and  about  150  cc.  of  the  latter  are 
necessary  for  1  gram  of  sulphate  of  a  cinchona  alkaloid.  Coniine, 
aconitine,  atropine,  veratrine,  codeine,  strychnine,  morphine  and  others 
are  not  adapted  for  estimation  in  this  manner;  but  reliable  results  are 
obtained  with  nicotine,  brucine,  berberine  and  the  cinchona  alkaloids. 
—Phar.  Centralhalle,  1881,  pp.  399,  400. 
Estimation  of  Quinine  as  Herapathite.  —  A.  Christensen,  from  a 
series  of  experiments  considers  De  Vrij's  method,  though  not  abso- 
lutely accurate,  the  best  yet  recommended,  and  arrives  at  the  following 
conclusions : 
1.  Acidulated  alcohol  dissolves  notable  quantities  of  herapathite, 
and  the  correctness  of  the  results  will  be  influenced  by  too  much  as 
well  as  by  too  little  acid. 
2.  The  concentration  of  the  liquid  may  influence  the  result. 
3.  Cinchonidine  periodosulphate  may  be  precipitated  in  the  pre- 
sence of  notable  quantities  of  that  alkaloid,  notwithstanding  the  pre- 
caution, recommended  by  De  Vrij,  of  adding  the  reagent  slowly,  and 
with  constant  stirring. 
4.  Quinine  iodosulphates,  with  more  iodine  than  is  contained  in 
herapathite,  may  be  formed,  unless  the  precipitation  is  effected  in  the 
