76 
Gleanings  in  Materia  Medica. 
Am.. Tour  Pharm. 
Feb.,  188-2. 
and  these,  on  being  converted  into  neutral  sulphate,  furnished  a  quan- 
tity of  pure  sulphate  of  ([uinine,  while  the  mother  liquor  contained 
quinidine. 
Perhaps  the  easiest  way  of  obtaining  this  compound  is  to  dissolve 
one  part  of  pure  quinine  in  30  or  40  parts  of  ether,  and  add  to  the 
liquid  a  saturated  etherial  solution  of  a  like  quantity  of  pure  quini- 
dine; a  crystalline  precipitate  forms  in  abundance,  which  is  much  less 
soluble  than  either  of  its  constituents,  100  cc.  of  ether  at  common 
temperatures  dissolving  only  0*5  gram  of  it. 
A  new  alkaloid,  called  cinchonamine,  has  !)een  obtained  by  Arnaud 
('^Rep  de  Phar.,"  Nov.,  1881,  p.  507-509)  from  a  bark  of  Santander, 
Columbia,  which  seems  to  belong  to  the  cuprea  barks  and  which  is 
described  as  being  very  dense,  of  a  deep  red-brown  color  and  having  a 
resinous  fracture.  The  hydrochlorate  of  the  new  alkaloid  is  easily 
separated  from  the  cinchonine,  also  present,  by  its  sparing  solubility  in 
cold  water.  The  alkaloid  is  insoluble  in  cold  water,  dissolves  in  100 
parts  of  ether,  sp.  gr.  '720,  and  in  31*6  parts  of  90  per  cent,  alcohol, 
crystallizes  from  boiling  alcohol  in  colorless  shining  anhydrous  prisms, 
melts  at  195°C.,  is  dextrogyre  (dissolved  in  alcohol  =  +117'9),  has 
a  slight  bitter  taste  and  yields  sparingly  soluble  neutral  salts,  which  in 
acid  solution  are  not  fluorescent.    Its  composition  is  C19H24N2O. 
O.  Hesse  ("Phar.  Jour,  and  Trans.,''  Dec.  24,  1881,  p.  517)  has 
found  in  a  cuprea  bark  considerable  quantities  of  aricine  and  cusconine, 
some  cinchonine,  and  a  small  quantity  of  an  alkaloid  that  had  a  great 
resemblance  to  cinchonine,  though  in  several  points  differing  essentially 
from  it.  The  bark  corresponded  in  fracture  and  hardness  to  the  true 
cuprea  bark,  but  had  a  pale  reddish  color.  The  cinchonamine  of 
Arnaud  stands  without  doubt  in  very  near  relation  to  aricine. 
Hesse  ("Berichte,"  1881,  p.  1683-1685)  has  also  obtained  a  new 
alkaloid,  cinchamidine,  €20^120^2^)  fractionally  precipitating  the 
mother  liquor  from  homocinchonidine  sulphate  with  neutral  sodium 
tartrate,  when  the  new  alkaloid  is  contained  in  the  last  precipitates. 
In  the  pure  state,  the  alkaloid  crystallizes  in  colorless  scales  and  flat 
needles,  or  from  strong  alcohol,  in  short  thick  prisms,  melts  at  230°C., 
is  levogyre  ( — 98*4°)  and  its  acid  solutions  are  neither  fluorescent  nor 
do  they  yield  a  green  color  with  chlorine  and  ammonia.  Its  sulphate 
has  about  the  same  solubility  as  the  sulphate  of  homocinchonidine,  and 
the  alkaloid  is  frequently  and  in  notable  quantities  present  in  com- 
mercial cinchonidine. 
