Am.  Ji>ur.  Pharni  } 
^  August,  1882.  f 
Quhdne  lodcdc  and  Bromate. 
417 
I  am  disposed  to  believe  that  the  chlorates^  bromates,  and  iodates 
are  more  active  physiological  agents  than  the  corresponding  chlorides, 
bromides,  and  iodides ;  they  are  all  composed  of  superoxidized  mole- 
cules. It  is  certain  that  chlorate  of  sodium  is  more  powerful  than 
chloride  of  sodium,  or  common  salt.  We  may  from  analogy  infer  that 
iodate  of  potassium  is  a  more  active  physiological  agent  than  the  iodide 
of  potassium. 
Ferric  Iodate. — Some  years  ago  I  suggested  the  use  of  ferric  iodate 
(Fe2(I03)6)  as  a  substitute  for  the  unstable  ferrous  iodide  ('^Dublin 
Quarterly  Journal  of  Medical  Science/^  May,  1869,  vol.  xlvii,  p.  354) 
It  was  largely  prescribed  in  Dublin,  and  although  a  nearly  insoluble 
salt,  it  was  found  in  large  doses  to  produce  iodism.  It  was  favorably 
noticed  by  Dr.  Anstie  in  ''The  Practitioner''  for  June,  1869,  p.  366. 
Quinine  Iodate. — Last  year  I  gave  a  formula  for  the  preparation  of 
iodate  of  quinine  in  combination  with  an  effervescing  preparation, 
to  Messrs.  J.  J.  Graham  &  Co.,  of  Westmoreland  street,  Dublin,  and 
since  last  May,  they  have,  as  they  inform  me,  disposed  of  nearly  1  cwt. 
of  the  compound.  It  has  been  prescribed  largely  by  Mr  Porter,  sur- 
geon to  her  Majesty,  Dr.  Samnel  Gordon,  Profesvsor  Moore,  Dr.  Smyly, 
Professor  Macnamara,  and  many  other  leading  practitioners.  These 
gentlemen  inform  me  that  they  have  found  it  a  very  useful  renieciy  in 
the  treatment  of  neuralgia,  severe  articular  pains  Avhich  had  resisted 
the  employment  of  the  usual  remedies,  sluggish  forms  of  pulmonary 
congestion,  secondary  syphilitic  disease,  and  malarial  enlargement  of 
the  spleen. 
Iodate  of  quinine  is  a  salt  which  appears  to  have  been  scarcely 
studied ;  only  two  references  to  its  existence  are  to  be  found  in  the 
books  and  journals  relating  to  chemistry  and  pharmacy.  Serullas 
states  Annales  de  Cliimie  et  de  Physique,  t.  xlv,  282,)  that  it  may 
be  prepared  by  dissolving  quinine  in  a  hot  solution  of  iodic  acid,  and 
that  on  cooling  the  solution  the  salt  crystallizes  out  in  a  form  resem- 
bling sulphate  of  quinine.  Serullas  does  not  appear  to  have  analyzed 
the  salt.  According  to  Pelletier  and  Caventou  ("Annales  de  Chimie 
et  de  Physique''),  both  iodate  and  hydriodate  of  quinine  are  formed  by 
digesting  quinine  and  iodine  by  the  aid  of  heat. 
Quinine  iodate  may  be  ])rei)ared  by  digesting  freshly  precipitated 
and  still  moist  quinine  with  a  warm  solution  of  iodic  acid,  in  the  pro- 
portion of  a  molecule  of  each  (the  iodic  acid  should  be  dissolved  in  8 
or  10  parts  of  water).    The  resulting  mass  cannot  be  dried  at  the  water- 
