418 
Quinine  lodaic  and  Bromafc. 
f  Am.  Jour.  Pbarm 
"(     August,  1882  - 
bath  heat  as  it  causes  some  decomposition  of  the  salt.  Dried  at  a  tem- 
perature of  60°F.,  and  then  placed  in  vacuo  over  sulphuric  acid,  it 
undergoes  no  further  loss  of  weight.  The  salt  has  a  white,  pearly 
appearance,  and  consists  of  extremely  minute  needle-shaped  crystals, 
which  contain  no  water ;  boiling  water  does  not  decompose  it ;  it  is 
very  slightly  affected  by  strong  sulphuric  acid ;  hydrochloric  acid  and 
dilute  sulphuric  acid  dissolve  it  readily;  it  is  not  quite  so  soluble  in 
acetic  acid.  Spirit  of  wine  effects  its  solution  readily,  but  in  ether  and 
chloroform  it  is  sparingly  soluble.  Seven  hundred  parts  of  cold  water 
dissolve  one  part  of  the  iodate  ;  in  warm  water  it  dissolves  much  more 
readily. 
The  mean  of  several  determinations  of  the  amount  of  iodine  in  the 
dried  iodate  of  quinine  gave  21 '8  per  cent. ;  the  salt  has  therefore  the 
following  formula :  020^2402X2,11103.  The  theoretical  amount  of 
iodine  for  such  a  formula  is  22*92,  but  the  small  deficiency  in  the  salt 
was  due  to  the  pi'fesence  of  a  little  free  quinine ;  the  iodate  was  found 
to  be  faintly  alkaline  from  this  cause. 
The  granulated  effervescing  iodate  of  quinine  is  composed  of  a  mix- 
ture of  the  pharmacopceia  compound  of  sodium  bicarbonate  and  citric 
and  tartaric  acids  with  the  iodate.  Each  drachm  of  the  compound 
contains  2  grains,  or  one  dose  of  the  iodate. 
I  have  not  made  many  examinations  of  the  urine  of  persons  under 
administration  of  (juinine  iodate.  In  the  case  of  a  patient  of  Dr. 
Elliott  who  was  using  the  iodate  for  about  a  fortnight,  the  urine  con- 
tained so  much  free  hydriodic  acid  or  iodides,  that  it  gave  a-  yellow 
precipitate  with  nitrate  of  lead.  In  another  case,  iodic  acid  and  hydri- 
odic acid  were  detected  in  the  urine  within  half  an  hour  after  the  iodate 
had  been  taken,  but  no  trace  of  quinine  could  be  found  in  it.  In  the 
urine  of  the  same  person,  passed  three  hours  later,  (piinine  was  found. 
Bromate  of  Quinine  (02oH24N202,HBrO.^). — I  can  find  no  account 
of  this  salt  in  the  chemical  books  or  journals ;  so  far  as  I  am  aware, 
it  has  not  been  described  up  to  the  present.  It  may  be  prepared  by 
precipitating  barium  brotuate  by  sulphate  of  quinine,  or  by  neutralizing 
quinine  with  bromic  acid.  It  occurs  when  air-dried  in  small  asbestos- 
like masses,  which,  under  the  microscope,  are  seen  to  consist  of  very 
long  needles. 
Quinine  bromate  has  the  same  constitution  as  the  iodate  of  quinine, 
but  it  is  more  soluble  in  water,  namely,  1  part  in  250.  Warm  water 
dissolves  it  freely.    The  dry  salt  may  be  heated  on  the  water-bath 
