436 
Solubility  of  Sulphates  of  Moi'phine. 
/Am.  Jour.  Pharni. 
\      Sept.,  1882. 
SOLUBILITY  OF  COMMERCIAL  SULPHATES  OF  MOR- 
PHINE. 
By  Virgil  Coblentz,  Ph. (I. 
An  article  on  tliis  subject  appeared  in  the  March  niiniber  of  this 
journal  by  Prof.  Power,  giving  the  conflicting  statements  on  tlu^ 
solubility  of  sulphate  of  morphine,  and  at  the  same  time  making  an 
accurate  determination  of  the  solubility  of  the  salt  as  made  by  Rosen- 
garten  &  Sons.  The  object  of  this  article  is  the  determination  of  the 
(liflFerences  in  the  degree  of  solubility  of  this  salt  as  produced  by 
different  manufocturers  and  found  in  our  markets.  The  method 
employed  to  determine  the  solubilities  is  that  recommended  by  Dr. 
Power,  viz. :  ''An  excess  of  sulphate  of  morphine  was  digested  witli 
distilled  water  at  15°C.  for  several  days  with  frequent  agitation,  and 
the  solution  filtered  from  the  excess  of  salt  (proper  temperature  being 
observed),  the  amount  of  sulphate  of  morphine  contained  therein  wa.s 
determined  by  precipitation  with  chloride  of  barium,  and  from  the 
ignited  amount  of  barium  sulphate  the  amount  of  crystallized  sulphate 
of  morphine,  (CiwHjgX03)2.H2S04-l-5H20,  Avas  inversely  calculated." 
Example. — 16*363  grams  of  cold  saturated  solution  gave '2650  gram 
of  sulphate  of  barium,  corresponding  to  '8625  gram  of  crystallized 
sulphate  of  morphine. 
(BaS04)232-8 :  (Cj^HigNOgj^HSO,  +  5H20)758  : :  -2650 :  x.  x  =  '8625 
gram  morphine  sulphate  crystallized. 
(Solution)  16-336  :  (Morph.  Salph.)  '8628  ::  100  :  x. 
x=:  5-272  per  cent.,  and  100  :  5-272  =  18*97  parts  of  w_ater. 
Weight  of 
One  part  of 
Sample. 
Solution. 
BaSO, 
Morph. 
Sulph. 
the  salt  solu- 
ble at  15.°  C.  in 
I. 
11-000  gm. 
•1580  gm. 
•5145  gm. 
21^38  water. 
H. 
21-808  " 
•2801  •• 
•!)12  " 
23-90  " 
in. 
17 -.508  " 
•232  " 
•7554  " 
23-18  " 
IV.  . 
13-020  " 
•226  " 
•7359 
17-69  " 
^- 
16-8G3  " 
•205  " 
•8625  " 
-18-97  " 
Average, 
21  -00  water. 
