Am.  Jour.  Pharm.  1 
Oct.,  1882.  I 
Two  Isomeric  Dibromocamphors. 
509 
The  insoluble  granules  can  be  easily  obtained  from  the  mucous  mem- 
brane of  a  pig's  stomach  from  which  all  mucus  has  been  removed. 
Thus  obtained  their  properties  agree  with  those  of  the  gastric  micro- 
zymas  of  Bechamp. — Jour.  Chem.  Soc,  Jnlj,  Aug.,  from  Compt.  rend.^ 
vol.  94. 
TWO  ISOMERIC  DIBROMOCAMPHORS  AND  MONOBRO- 
MOCAMPHOR. 
By  J.  Kaohler  and  F.  V.  Spitzer. 
Monobromocamphor,  discovered  by  Perkin  in  1865,  forms  color- 
less monoclinic  crystals,  melts  at  76°,  boils  without  decomposition  at 
274°,  and  is  reconverted  into  camphor  by  the  action  of  alcoholic 
potash,  or  by  heating  it  in  alcoholic  solution  with  sodium-amalgam. 
R.  Schiff,  by  heating  it  with  nitric  acid,  obtained  a  crystalline  substance,, 
C10H14NO3,  which  he  regarded  as  bromonitrocamphor. 
By  the  further  action  of  bromine  monobromocamphor  is  converted 
into  dibromocamphor,  the  statements  respecting  which  by  different 
authors  exhibit  considerable  divergencies,  due,  as  the  following  exper- 
iments will  show,  to  the  existence,  not  previously  suspected,  of  two 
isomeric  dibromocamphors  («  and  /?). 
a-Dibromocamphor  is  obtained  by  heating  1  mol.  monobromocamphor 
with  1  mol.  bromine  in  sealed  tubes  at  120°,  and  separates  from  the 
resulting  syrupy  liquid  as  a  crystalline  mass,  which  dissolves  with 
moderate  facility  in  alcohol,  and  is  deposited  therefrom  in  prismatic 
needles  melting  at  61°. 
^-Dibromocamphor  is  obtained  by  heating  monobromocamphor  with 
bromine  in  the  ratio  of  CjoH^gBrO  to  3Br  for  six  or  eight  hours  in 
sealed  tubes  at  120  to  125°,  whereby  a  brown  sprup  is  formed,  which 
slowly  deposits  crystals,  and  when  mixed  with  absolute  alcohol,  imme- 
diately yields  a  pulverulent  crystalline  mass,  only  slightly  soluble  in 
alcohol,  even  at  the  boiling  heat,  and  separating  from  the  solution  in 
thick  rectangular  plates,  having  also  the  composition  CioH^^Br^O,  but 
melting  at  114  to  115°.  The  mother-liquor  contains  monobromo- 
camphor. The  ^^-modification  of  dibromocamphor  is  also  formed  by 
heating  the  ^-modification  with  2  at.  bromine  in  sealed  tubes  at 
120  to  125°  for  six  to  eight  hours.  A  red  laminar  sublimate  then 
forms  in  the  upper  part  of  the  tube,  apparently  consisting  of  an  unstable 
compound  of  Q^^^fir^O  with  bromine,  which  it  gradually  gives  off, 
