334 
CHLORODYNE. 
As  the  heat  must  not  rise  above  100°  F.  the  material  employ- 
ed if  not  sufficiently  fluid  at  that  temperature  must  be  thinned 
with  spirits  of  turpentine  until  the  requisite  fluidity  is  secured. 
The  materials  are  first  strained  through  a  coarse  sieve  of  tinned 
copper,  and  then  through  a  cloth  sufficiently  fine  to  retain  all 
the  impurities  mechanically  suspended  in  them.  The  filtered 
turpentine  is  then  to  be  distilled  in  a  current  of  steam  in  vacuo, 
until  no  more  spirits  of  turpentine  come  over.  The  resin  re- 
maining in  the  still  is  almost  colorless,  and  fit  for  employment 
in  all  cases  which  demand  the  use  of  virgin  resin. 
The  practical  simplicity  and  the  commercial  importance  of  the 
process  developed  in  this  patent  are  so  obvious  as  to  require  no 
comment. — Chem.  News,  London,  May  12th,  1860. 
CHLORODYNE : 
Its  History,  Preparation,  Properties,  Therapeutic  Effects,  Doses,  &c. 
History. — Chlorodyne  was  invented  in  the  year  '48  by  Dr. 
Browne,  whilst  officiating  in  his  medical  capacity  during  the 
prevalence  of  cholera  and  diarrhoea  amongst  our  troops  in 
India,  and  was  introduced  to  the  notice  of  the  faculty  in  this 
country  by  him  as  "  a  combination  of  perchloric  acid  with  a  new 
alkaloid." 
Preparation  From  Dr.  Ogden's  analysis  it  appears  to  be 
composed  as  follows : — Chloroform,  six  drachms  ;  tincture  of 
capsicum,  half  a  drachm ;  oil  of  peppermint,  three  drops  ;  mu- 
riate of  morphia,  eight  grains  ;  perchloric  acid,  twenty  drops  ; 
Steele's  hydrocyanic  acid,  twelve  drops  ;  tincture  of  Indian 
hemp,  one  drachm ;  treacle,  one  drachm.  Dissolve  the  morphia 
in  the  perchloric  acid  ;  then  add  the  tincture  of  hemp,  capsicum 
peppermint,  and  chloroform,  and  lastly,  treacle  and  prussic  acid. 
Properties. — Chlorodyne  is  a  volatile  liquid  possessing  a 
pungent  smell  and  taste.  It  is  soluble  in  alcohol,  but  insoluble 
in  water  ;  but  may  be  conveniently,  administered  in  that  liquid 
by  suspending  it  in  a  little  mucilage.  The  alkalies  and  alkaline 
salts  decompose  it.  In  color  it  is  dark  brown,  and  in  weight 
equal  to  twice  its  bulk  of  water.  It  is  anodyne,  sedative,  dia- 
phoretic, astringent,  antispasmodic,  diuretic,  &c.  Unlike  the  pre- 
parations of  opium,  it  does  not  producehe  adache,  giddiness,  pro- 
