410 
ON  HYPOPHOSPHITB  OF  QUINIA. 
as  none  of  our  correspondents  have  referred  to  its  origin.  The 
Pacific  Medical  Journal  for  May  repudiates  the  idea  of  its  pos- 
sessing any  deleterious  properties.  Cannot  some  of  our  friends 
give  the  history  of  this  substance  ? 
HYPOPHOSPI1ITE  OF  QUINIA. 
By  J.  Lawrence  Smith,  M.  D. 
Professor  of  Chemistry,  University  of  Louisville. 
I  brought  this  article  to  public  notice  a  short  time  ago, 
through  the  pages  of  this  Journal.  As  I  was  not  then  pre- 
pared to  give  a  statement  of  its  composition,  that  omission  will 
now  be  made  up. 
In  100  parts  there  is 
Quinine,  83.00 
Hypophosphorous  acid,        .        .        .    10  09 
Water  of  combination,         .        .        .  2.30 
Water  of  crystallization,      .        .         .  4.60 
Giving  the  formula":  C40H24N2O4,PO,HO+2  aq. ;  or,  according 
to  Gerhardt's  method  of  statement,  just  double  that  formula. 
Its  physical  characters  have  been  fully  described. 
The  manner  in  which  it  is  manufactured  at  the  Louisville 
Chemical  Works  is  as  follows: — 50  ounces  of  sulphate  of  qui- 
nine is  placed  in  a  large  porcelain  capsule  ;  to  this  is  added  2 
gallons  of  distilled  water,  and  2  ounces  of  hypophosphorous  acid. 
Warm  up  to  about  200°  R,  and  make  a  perfect  magma  of  the 
sulphate  of  quinine  and  water,  then  add  a  solution  of  hypophos- 
phite  of  baryta  until  a  perfect  decomposition  is  produced. 
Great  care  must  be  taken  to  have  no  excess  of  baryta  salt ;  bet- 
ter have  a  slight  excess  of  sulphate  of  quinine.  But  a  little 
skill  will  enable  a  competent  operator  to  obtain  an  exact  neu- 
tralization. While  warm,  the  solution  of  hypophosphite  of 
quinine  is  filtered  off  from  the  sulphate  of  baryta  and  allowed 
to  crystallize.  The  sulphate  of  baryta  is  then  washed,  and  the 
washings  added  to  the  mother  water  of  the  first  crystallization, 
and  evaporated  with  great  care,  when  other  crystals  may  be  ob- 
tained. If  not  carefully  evaporated,  it  will  become  colored. 
The  crystals  are  drained  and  dried  on  a  cloth  stretcher. 
Louisville,  (Ky.,)  Aug.  20th,  1860. 
