Am.  Jour.  Pharm.  \ 
March,  1887.  J 
New  Crystalline  Acid  in  Urine. 
135 
face  of  the  liquid  (due  to  absorption  of  oxygen).  Oxyphenic  acid 
gives  an  almost  similar  reaction,  only  that  a  green  coloration  is  first 
produced,  which  is  not  the  case  with  the  other  acid.  The  brownish 
coloration  noticed  when  the  diluted  urine  containing  the  acid  is  added 
to  Fehling's  solution,  is  partly  due  to  the  action  of  the  alkali  of  the 
Fehling's  solution  upon  the  acid. 
Picric  acid  causes  no  change.  Upon  the  addition  of  sodium  hydrate 
to  the  mixture  of  the  acid  and  picric  acid,  a  brownish  coloration  is 
produced,  similar  to  that  produced  by  sodium  hydrate  alone. 
No  reduction  of  the  bismuth  salt  in  Bottger's  test  occurs  with  the 
acid. 
The  acid  responds  to  Trominer's  test,  as  also  to  Fehling's  test. 
Argentic  nitrate  is  reduced  in  the  cold  by  the  acid. 
The  fermentation  test  fails  completely. 
Its  aqueous  solution  has  no  effect  upon  polarized  light. 
Upon  the  addition  in  turn  of  a  dilute  neutral  solution  of  ferric  chlo- 
ride, ammonium  hydrate,  and  acetic  acid,  the  play  of  colors  from 
green  to  violet,  and  then  to  green  as  with  oxyphenic  acid,  does  not  oc- 
cur.   It  does  not  respond  to  the  tests  for  hydrochinon. 
With  a  dilute  neutral  solution  of  ferric  chloridea  blue  coloration  is  pro- 
duced which  very  soon  disappears.  From  this  reaction  the  acid  is  most 
likely  a  phenol  derivative.  It  forms  lead,  barium,  and  calcium 
salts. 
The  lead  salt  crystallizes  in  heavy  needle-like  prisms,  melting  at 
209*5°  C.  It  is  soluble  in  hot  water,  insoluble  in  benzol,  toluol,  pe- 
troleum ether,  absolute  or  ordinary  alcohol,  ethyl  ether,  and  chloro- 
form. It  is  decomposed  when  passed  through  animal  charcoal,  the 
acid  remaining  in  the  charcoal  and  the  lead  coming  through  with  the 
filtrate  as  oxide. 
On  account  of  insufficiency  of  pure  material — acid  and  lead  salt — 
no  ultimate  analysis  has  thus  far  been  made.  In  a  short  time  I  hope 
to  have  enough  material  for  that  purpose,  and  then  a  formula  for  the 
acid  can  be  constructed,  and  more  learned  regarding  its  source  in  the 
human  organism.  However,  two  lead  determinations  in  the  lead  salt 
have  been  made  : 
0*1166  gramme  lead  salt  gave  0.0717  gramme  PbS(\,  equiva'ent 
to  33.50  per  cent,  of  lead. 
0*1314  gramme  lead  salt  gave  0*0649  gramme  PbSG4,  equivalent 
to  33*66  per  cent,  of  lead. 
